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10.3346/jkms.2010.25.9.1296 http://scihub22266oqcxt.onion/10.3346/jkms.2010.25.9.1296 20808672!2923799!20808672     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20808672.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Korean+Med+Sci 2010 ; 25 (9): 1296-304 Nephropedia Template TP {{tp|p=20808672|t=2010. Aldosterone modulates cell proliferation and apoptosis in the neonatal rat heart |pdf=|usr=}}{{20808672}} gab.com Text Aldosterone modulates cell proliferation and apoptosis in the neonatal rat heart JO: J Korean Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=20808672 #FOAvip In the present study, we investigated whether and how the mineralocorticoid receptor antagonist spironolactone affects cardiac growth and development through apoptosis and cell proliferation in the neonatal rat heart. Newborn rat pups were treated with spironolactone (200 mg/kg/d) for 7 days. The cell proliferation was studied by PCNA immunostaining. The treatment with spironolactone decreased proliferating myocytes by 32% (P<0.05), and reduced myocytes apoptosis by 29% (P<0.05). Immunoblot and immunohistochemistry for the expression of p38, p53, clusterin, TGF-beta2, and extracellular signal-regulated kinase were performed. In the spironolactone group, p38, p53, clusterin, and TGF-beta2 protein expression was significantly decreased (P<0.05). These results indicate that aldosterone inhibition in the developing rat heart induces cardiac growth impairment by decreasing proliferation and apoptosis of myocytes. Twit Text FOAVip Aldosterone modulates cell proliferation and apoptosis in the neonatal rat heart ????J Korean Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=20808672 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20808672 #FOAvip English Wikipedia <ref>{{Cite pmid|20808672}}</ref> Aldosterone modulates cell proliferation and apoptosis in the neonatal rat heart #MMPMID20808672 Sohn HJ; Yoo KH; Jang GY; Lee JH; Choi BM; Lee JH; Bae IS; Yim HE; Son CS; Lee JW J Korean Med Sci 2010[Sep]; 25 (9): 1296-304 PMID20808672show ga In the present study, we investigated whether and how the mineralocorticoid receptor antagonist spironolactone affects cardiac growth and development through apoptosis and cell proliferation in the neonatal rat heart. Newborn rat pups were treated with spironolactone (200 mg/kg/d) for 7 days. The cell proliferation was studied by PCNA immunostaining. The treatment with spironolactone decreased proliferating myocytes by 32% (P<0.05), and reduced myocytes apoptosis by 29% (P<0.05). Immunoblot and immunohistochemistry for the expression of p38, p53, clusterin, TGF-beta2, and extracellular signal-regulated kinase were performed. In the spironolactone group, p38, p53, clusterin, and TGF-beta2 protein expression was significantly decreased (P<0.05). These results indicate that aldosterone inhibition in the developing rat heart induces cardiac growth impairment by decreasing proliferation and apoptosis of myocytes. |*Apoptosis[MESH] |Animals[MESH] |Animals, Newborn[MESH] |Cell Proliferation[MESH] |Clusterin/genetics/metabolism[MESH] |Female[MESH] |Heart/*drug effects/growth & development[MESH] |Mineralocorticoid Receptor Antagonists/*pharmacology[MESH] |Proliferating Cell Nuclear Antigen/metabolism[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Spironolactone/*pharmacology[MESH] |Transforming Growth Factor beta2/genetics/metabolism[MESH] |Tumor Suppressor Protein p53/genetics/metabolism[MESH]Aldosterone modulates cell proliferation and apoptosis in the neonatal(epmc).pdf DeepDyve Pubget Overpricing