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10.1096/fj.10-161612 http://scihub22266oqcxt.onion/10.1096/fj.10-161612 20837776!3005421!20837776     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20837776.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       FASEB+J 2011 ; 25 (1): 16-28 Nephropedia Template TP {{tp|p=20837776|t=2011. Endothelin-1 gene regulation |pdf=|usr=}}{{20837776}} gab.com Text Endothelin-1 gene regulation JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=20837776 #FOAvip Over two decades of research have demonstrated that the peptide hormone endothelin-1 (ET-1) plays multiple, complex roles in cardiovascular, neural, pulmonary, reproductive, and renal physiology. Differential and tissue-specific production of ET-1 must be tightly regulated in order to preserve these biologically diverse actions. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (edn1). Studies conducted on a variety of cell types have identified key transcription factors that govern edn1 expression. With few exceptions, the cis-acting elements bound by these factors have been mapped in the edn1 regulatory region. Recent evidence has revealed new roles for some factors originally believed to regulate edn1 in a tissue or hormone-specific manner. In addition, other mechanisms involved in epigenetic regulation and mRNA stability have emerged as important processes for regulated edn1 expression. The goal of this review is to provide a comprehensive overview of the specific factors and signaling systems that govern edn1 activity at the molecular level. Twit Text FOAVip Endothelin-1 gene regulation ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=20837776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20837776 #FOAvip English Wikipedia <ref>{{Cite pmid|20837776}}</ref> Endothelin-1 gene regulation #MMPMID20837776 Stow LR; Jacobs ME; Wingo CS; Cain BD FASEB J 2011[Jan]; 25 (1): 16-28 PMID20837776show ga Over two decades of research have demonstrated that the peptide hormone endothelin-1 (ET-1) plays multiple, complex roles in cardiovascular, neural, pulmonary, reproductive, and renal physiology. Differential and tissue-specific production of ET-1 must be tightly regulated in order to preserve these biologically diverse actions. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (edn1). Studies conducted on a variety of cell types have identified key transcription factors that govern edn1 expression. With few exceptions, the cis-acting elements bound by these factors have been mapped in the edn1 regulatory region. Recent evidence has revealed new roles for some factors originally believed to regulate edn1 in a tissue or hormone-specific manner. In addition, other mechanisms involved in epigenetic regulation and mRNA stability have emerged as important processes for regulated edn1 expression. The goal of this review is to provide a comprehensive overview of the specific factors and signaling systems that govern edn1 activity at the molecular level. |*Gene Expression Regulation[MESH] |Animals[MESH] |Binding Sites/genetics[MESH] |Endothelin-1/*genetics[MESH] |Epigenomics[MESH] |Humans[MESH] |Protein Binding[MESH] |RNA Stability[MESH] |Regulatory Sequences, Nucleic Acid/*genetics[MESH]Endothelin-1 gene regulation (epmc).pdf DeepDyve Pubget Overpricing