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10.1152/ajprenal.00521.2010 http://scihub22266oqcxt.onion/10.1152/ajprenal.00521.2010 20926630!3006309!20926630     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\20926630.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Renal+Physiol 2010 ; 299 (6): F1237-44 Nephropedia Template TP {{tp|p=20926630|t=2010. Drosophila provides rapid modeling of renal development, function, and disease |pdf=|usr=}}{{20926630}} gab.com Text Drosophila provides rapid modeling of renal development, function, and disease JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=20926630 #FOAvip The evolution of specialized excretory cells is a cornerstone of the metazoan radiation, and the basic tasks performed by Drosophila and human renal systems are similar. The development of the Drosophila renal (Malpighian) tubule is a classic example of branched tubular morphogenesis, allowing study of mesenchymal-to-epithelial transitions, stem cell-mediated regeneration, and the evolution of a glomerular kidney. Tubule function employs conserved transport proteins, such as the Na(+), K(+)-ATPase and V-ATPase, aquaporins, inward rectifier K(+) channels, and organic solute transporters, regulated by cAMP, cGMP, nitric oxide, and calcium. In addition to generation and selective reabsorption of primary urine, the tubule plays roles in metabolism and excretion of xenobiotics, and in innate immunity. The gene expression resource FlyAtlas.org shows that the tubule is an ideal tissue for the modeling of renal diseases, such as nephrolithiasis and Bartter syndrome, or for inborn errors of metabolism. Studies are assisted by uniquely powerful genetic and transgenic resources, the widespread availability of mutant stocks, and low-cost, rapid deployment of new transgenics to allow manipulation of renal function in an organotypic context. Twit Text FOAVip Drosophila provides rapid modeling of renal development, function, and disease ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=20926630 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20926630 #FOAvip English Wikipedia <ref>{{Cite pmid|20926630}}</ref> Drosophila provides rapid modeling of renal development, function, and disease #MMPMID20926630 Dow JA; Romero MF Am J Physiol Renal Physiol 2010[Dec]; 299 (6): F1237-44 PMID20926630show ga The evolution of specialized excretory cells is a cornerstone of the metazoan radiation, and the basic tasks performed by Drosophila and human renal systems are similar. The development of the Drosophila renal (Malpighian) tubule is a classic example of branched tubular morphogenesis, allowing study of mesenchymal-to-epithelial transitions, stem cell-mediated regeneration, and the evolution of a glomerular kidney. Tubule function employs conserved transport proteins, such as the Na(+), K(+)-ATPase and V-ATPase, aquaporins, inward rectifier K(+) channels, and organic solute transporters, regulated by cAMP, cGMP, nitric oxide, and calcium. In addition to generation and selective reabsorption of primary urine, the tubule plays roles in metabolism and excretion of xenobiotics, and in innate immunity. The gene expression resource FlyAtlas.org shows that the tubule is an ideal tissue for the modeling of renal diseases, such as nephrolithiasis and Bartter syndrome, or for inborn errors of metabolism. Studies are assisted by uniquely powerful genetic and transgenic resources, the widespread availability of mutant stocks, and low-cost, rapid deployment of new transgenics to allow manipulation of renal function in an organotypic context. |Animals[MESH] |Animals, Genetically Modified[MESH] |Cilia/physiology[MESH] |Disease Models, Animal[MESH] |Drosophila Proteins/genetics[MESH] |Drosophila/*physiology[MESH] |Humans[MESH] |Ion Transport[MESH] |Kidney Diseases/*physiopathology[MESH] |Kidney/growth & development/*physiology[MESH] |Malpighian Tubules/*physiology[MESH] |Metabolism, Inborn Errors/physiopathology[MESH] |Models, Animal[MESH] |Nephrolithiasis/genetics[MESH] |Organogenesis[MESH]Drosophila provides rapid modeling of renal development, function, and(epmc).pdf DeepDyve Pubget Overpricing