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10.1681/ASN.2009121311 http://scihub22266oqcxt.onion/10.1681/ASN.2009121311 21115613!3014041!21115613     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21115613.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Nephrol 2011 ; 22 (1): 124-36 Nephropedia Template TP {{tp|p=21115613|t=2011. Klotho deficiency causes vascular calcification in chronic kidney disease |pdf=|usr=}}{{21115613}} gab.com Text Klotho deficiency causes vascular calcification in chronic kidney disease JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=21115613 #FOAvip Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and experimental Klotho deficiency, but whether Klotho deficiency is responsible for the calcification in CKD is unknown. Here, wild-type mice with CKD had very low renal, plasma, and urinary levels of Klotho. In humans, we observed a graded reduction in urinary Klotho starting at an early stage of CKD and progressing with loss of renal function. Despite induction of CKD, transgenic mice that overexpressed Klotho had preserved levels of Klotho, enhanced phosphaturia, better renal function, and much less calcification compared with wild-type mice with CKD. Conversely, Klotho-haploinsufficient mice with CKD had undetectable levels of Klotho, worse renal function, and severe calcification. The beneficial effect of Klotho on vascular calcification was a result of more than its effect on renal function and phosphatemia, suggesting a direct effect of Klotho on the vasculature. In vitro, Klotho suppressed Na(+)-dependent uptake of phosphate and mineralization induced by high phosphate and preserved differentiation in vascular smooth muscle cells. In summary, Klotho is an early biomarker for CKD, and Klotho deficiency contributes to soft-tissue calcification in CKD. Klotho ameliorates vascular calcification by enhancing phosphaturia, preserving glomerular filtration, and directly inhibiting phosphate uptake by vascular smooth muscle. Replacement of Klotho may have therapeutic potential for CKD. Twit Text FOAVip Klotho deficiency causes vascular calcification in chronic kidney disease ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=21115613 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21115613 #FOAvip English Wikipedia <ref>{{Cite pmid|21115613}}</ref> Klotho deficiency causes vascular calcification in chronic kidney disease #MMPMID21115613 Hu MC; Shi M; Zhang J; Quinones H; Griffith C; Kuro-o M; Moe OW J Am Soc Nephrol 2011[Jan]; 22 (1): 124-36 PMID21115613show ga Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and experimental Klotho deficiency, but whether Klotho deficiency is responsible for the calcification in CKD is unknown. Here, wild-type mice with CKD had very low renal, plasma, and urinary levels of Klotho. In humans, we observed a graded reduction in urinary Klotho starting at an early stage of CKD and progressing with loss of renal function. Despite induction of CKD, transgenic mice that overexpressed Klotho had preserved levels of Klotho, enhanced phosphaturia, better renal function, and much less calcification compared with wild-type mice with CKD. Conversely, Klotho-haploinsufficient mice with CKD had undetectable levels of Klotho, worse renal function, and severe calcification. The beneficial effect of Klotho on vascular calcification was a result of more than its effect on renal function and phosphatemia, suggesting a direct effect of Klotho on the vasculature. In vitro, Klotho suppressed Na(+)-dependent uptake of phosphate and mineralization induced by high phosphate and preserved differentiation in vascular smooth muscle cells. In summary, Klotho is an early biomarker for CKD, and Klotho deficiency contributes to soft-tissue calcification in CKD. Klotho ameliorates vascular calcification by enhancing phosphaturia, preserving glomerular filtration, and directly inhibiting phosphate uptake by vascular smooth muscle. Replacement of Klotho may have therapeutic potential for CKD. |Adult[MESH] |Aged[MESH] |Animals[MESH] |Biomarkers/metabolism[MESH] |Calcinosis/etiology/metabolism/*physiopathology[MESH] |Calcium/metabolism[MESH] |Case-Control Studies[MESH] |Cell Line[MESH] |Chronic Disease[MESH] |Disease Models, Animal[MESH] |Disease Progression[MESH] |Dogs[MESH] |Female[MESH] |Glucuronidase/*deficiency/genetics/metabolism/urine[MESH] |Humans[MESH] |Kidney Diseases/complications/metabolism/*physiopathology[MESH] |Klotho Proteins[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C3H[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Mice, Transgenic[MESH] |Middle Aged[MESH] |Muscle, Smooth, Vascular/metabolism/*physiopathology[MESH] |Phosphates/metabolism[MESH]Klotho deficiency causes vascular calcification in chronic kidney dise(epmc).pdf DeepDyve Pubget Overpricing