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10.1089/thy.2010.0307 http://scihub22266oqcxt.onion/10.1089/thy.2010.0307 21190433!�!21190433 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21190433&cmd=llinks): Failed to open stream: HTTP request failed! 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Parvovirus B19 infection in Hashimoto s thyroiditis, papillary thyroid carcinoma, and anaplastic thyroid carcinoma |pdf=|usr=}}{{21190433}} gab.com Text Parvovirus B19 infection in Hashimoto s thyroiditis, papillary thyroid carcinoma, and anaplastic thyroid carcinoma JO: Thyroid http://www.kidney.de/pget.php?&tw=1&pmid=21190433 #FOAvip BACKGROUND: The human pathogenic parvovirus B19 (B19) has recently been detected in papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) tissues at a high frequency in two studies of a Chinese cohort. We wanted to extend these data to include another cohort and expand the thyroid tumor tissue types assessed. In particular, we were interested to find whether B19 also infects anaplastic thyroid carcinoma (ATC), one of the most aggressive human cancers. METHODS: Commercially available thyroid tumor tissue arrays were used to detect B19 capsid protein by immunohistochemistry in various types of thyroid tumors and disorders. The arrays were representative of the four main types of thyroid tumors, as well as other thyroid autoimmune disorders such as HT and Graves' disease, and adenomas, goiters, lymphomas, and normal thyroid tissue. In total, at least 12 different types of thyroid conditions as well as normal tissue were represented, many with multiple subjects. RESULTS: Twenty-one of the 24 (88%) PTC tumors, 3 of the 3 ATC/undifferentiated tumors, and 3 of the 3 HT tissue samples were positive for B19 capsid protein by immunohistochemistry. The localization of the protein differed based on pathological disease type, with a nuclear to cytoplasmic shift seen from unaffected to tumor tissue. CONCLUSIONS: We extend the data available on B19 detection in the thyroid to show a high correlation of virus in another cohort of PTC and HT at the protein level. We also show, for the first time, B19 infection of much more highly aggressive ATC/undifferentiated tumors. Nuclear to cytoplasmic shift in B19 protein in cancer tissue suggests a possible link between B19 and thyroid cancer pathogenesis/progression. Twit Text FOAVip Parvovirus B19 infection in Hashimoto s thyroiditis, papillary thyroid carcinoma, and anaplastic thyroid carcinoma ????Thyroid http://www.kidney.de/pget.php?&tw=1&pmid=21190433 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21190433 #FOAvip English Wikipedia <ref>{{Cite pmid|21190433}}</ref> Parvovirus B19 infection in Hashimoto s thyroiditis, papillary thyroid carcinoma, and anaplastic thyroid carcinoma #MMPMID21190433 Adamson LA; Fowler LJ; Clare-Salzler MJ; Hobbs JA Thyroid 2011[Apr]; 21 (4): 411-7 PMID21190433show ga BACKGROUND: The human pathogenic parvovirus B19 (B19) has recently been detected in papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) tissues at a high frequency in two studies of a Chinese cohort. We wanted to extend these data to include another cohort and expand the thyroid tumor tissue types assessed. In particular, we were interested to find whether B19 also infects anaplastic thyroid carcinoma (ATC), one of the most aggressive human cancers. METHODS: Commercially available thyroid tumor tissue arrays were used to detect B19 capsid protein by immunohistochemistry in various types of thyroid tumors and disorders. The arrays were representative of the four main types of thyroid tumors, as well as other thyroid autoimmune disorders such as HT and Graves' disease, and adenomas, goiters, lymphomas, and normal thyroid tissue. In total, at least 12 different types of thyroid conditions as well as normal tissue were represented, many with multiple subjects. RESULTS: Twenty-one of the 24 (88%) PTC tumors, 3 of the 3 ATC/undifferentiated tumors, and 3 of the 3 HT tissue samples were positive for B19 capsid protein by immunohistochemistry. The localization of the protein differed based on pathological disease type, with a nuclear to cytoplasmic shift seen from unaffected to tumor tissue. CONCLUSIONS: We extend the data available on B19 detection in the thyroid to show a high correlation of virus in another cohort of PTC and HT at the protein level. We also show, for the first time, B19 infection of much more highly aggressive ATC/undifferentiated tumors. Nuclear to cytoplasmic shift in B19 protein in cancer tissue suggests a possible link between B19 and thyroid cancer pathogenesis/progression. |*Parvovirus B19, Human[MESH] |Capsid Proteins/analysis[MESH] |Carcinoma[MESH] |Carcinoma, Papillary/pathology[MESH] |Hashimoto Disease/pathology/*virology[MESH] |Humans[MESH] |Immunohistochemistry[MESH] |Parvoviridae Infections/*virology[MESH] |Thyroid Cancer, Papillary[MESH] |Thyroid Carcinoma, Anaplastic[MESH] |Thyroid Gland/virology[MESH] |Thyroid Neoplasms/pathology/virology[MESH]Parvovirus B19 infection in Hashimoto s thyroiditis, papillary thyroid(epmc).pdf DeepDyve Pubget Overpricing