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10.1111/j.1365-2265.2011.04148.x http://scihub22266oqcxt.onion/10.1111/j.1365-2265.2011.04148.x 21699555!ä!21699555 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21699555.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Endocrinol+(Oxf) 2011 ; 75 (6): 725-9 Nephropedia Template TP {{tp|p=21699555|t=2011. Mineralocorticoid antagonism: a novel way to treat sarcopenia and physical impairment in older people?|pdf=|usr=}}{{21699555}} gab.com Text Mineralocorticoid antagonism: a novel way to treat sarcopenia and physical impairment in older people JO: Clin Endocrinol (Oxf) http://www.kidney.de/pget.php?&tw=1&pmid=21699555 #FOAvip Dysregulation of the renin-angiotensin-aldosterone system has been associated with a number of age-related pathologies including hypertension, heart failure and chronic kidney disease. More recently, it has been suggested that alterations within the RAAS may contribute to the development of sarcopenia and subsequent decline in physical function. There is growing interest in developing interventions to prevent age-associated decline in muscle function. We postulate that inhibition of the RAAS with the mineralocorticoid antagonist spironolactone may have a role in countering the effects of physical impairment in older people by improving skeletal muscle function. Spironolactone may prevent skeletal myocyte apoptosis, improve vascular endothelial function and enhance muscle contractility by increasing muscle magnesium and sodium-potassium pumps. This article will review the literature underpinning the hypothesis that spironolactone may have a role in maintaining muscle function in older people. Twit Text FOAVip Mineralocorticoid antagonism: a novel way to treat sarcopenia and physical impairment in older people ????Clin Endocrinol (Oxf) http://www.kidney.de/pget.php?&tw=1&pmid=21699555 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21699555 #FOAvip English Wikipedia <ref>{{Cite pmid|21699555}}</ref> Mineralocorticoid antagonism: a novel way to treat sarcopenia and physical impairment in older people? #MMPMID21699555 Burton LA; McMurdo ME; Struthers AD Clin Endocrinol (Oxf) 2011[Dec]; 75 (6): 725-9 PMID21699555show ga Dysregulation of the renin-angiotensin-aldosterone system has been associated with a number of age-related pathologies including hypertension, heart failure and chronic kidney disease. More recently, it has been suggested that alterations within the RAAS may contribute to the development of sarcopenia and subsequent decline in physical function. There is growing interest in developing interventions to prevent age-associated decline in muscle function. We postulate that inhibition of the RAAS with the mineralocorticoid antagonist spironolactone may have a role in countering the effects of physical impairment in older people by improving skeletal muscle function. Spironolactone may prevent skeletal myocyte apoptosis, improve vascular endothelial function and enhance muscle contractility by increasing muscle magnesium and sodium-potassium pumps. This article will review the literature underpinning the hypothesis that spironolactone may have a role in maintaining muscle function in older people. |*Mineralocorticoid Receptor Antagonists/*therapeutic use[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Aging/drug effects/physiology[MESH] |Humans[MESH] |Mobility Limitation[MESH] |Motor Activity/*drug effects[MESH] |Restraint, Physical/physiology[MESH] |Sarcopenia/*drug therapy[MESH]Mineralocorticoid antagonism: a novel way to treat sarcopenia and phys(epmc).pdf DeepDyve Pubget Overpricing