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Tyrosine kinase signaling in kidney glomerular podocytes #MMPMID21776384
Hattori S; Kanda S; Harita Y
J Signal Transduct 2011[]; 2011 (ä): 317852 PMID21776384show ga
During the last decade, several key molecules have been identified as essential components for the filtration barrier function of kidney glomerular podocytes. Mutations in genes encoding these molecules severely impair the podocyte architecture in the affected patients, leading to the development of proteinuria. Extensive investigations have been performed on the function of these molecules, which highlights the importance of tyrosine kinase signaling in the podocytes. An Src family tyrosine kinase, Fyn, plays a major role in this signaling pathway. Here, we review the current understanding of this important signal transduction system and its role in the development and the maintenance of podocytes.