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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1189/jlb.0411184 http://scihub22266oqcxt.onion/10.1189/jlb.0411184 22003207!ä!22003207 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22003207&cmd=llinks): Failed to open stream: HTTP request failed! 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Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection |pdf=|usr=}}{{22003207}} gab.com Text Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=22003207 #FOAvip Little is known of how a strong immune response in the lungs is regulated to minimize tissue injury during severe influenza A virus (IAV) infection. Here, using a model of lethal, high-pathogenicity IAV infection, we first show that Ly6C(hi)Ly6G(-) inflammatory monocytes, and not neutrophils, are the main infiltrate in lungs of WT mice. Mice devoid of iNKT cells (Jalpha18(-/-) mice) have increased levels of inflammatory monocytes, which correlated with increased lung injury and mortality (but not viral load). Activation of iNKT cells correlated with reduction of MCP-1 levels and improved outcome. iNKT cells were able to selectively lyse infected, MCP-1-producing monocytes in vitro, in a CD1d-dependent process. Our study provides a detailed profile and kinetics of innate immune cells in the lungs during severe IAV infection, highlighting inflammatory monocytes as the major infiltrate and identifying a role for iNKT cells in control of these cells and lung immune-pathology. Twit Text FOAVip Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=22003207 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22003207 #FOAvip English Wikipedia <ref>{{Cite pmid|22003207}}</ref> Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection #MMPMID22003207 Kok WL; Denney L; Benam K; Cole S; Clelland C; McMichael AJ; Ho LP J Leukoc Biol 2012[Mar]; 91 (3): 357-68 PMID22003207show ga Little is known of how a strong immune response in the lungs is regulated to minimize tissue injury during severe influenza A virus (IAV) infection. Here, using a model of lethal, high-pathogenicity IAV infection, we first show that Ly6C(hi)Ly6G(-) inflammatory monocytes, and not neutrophils, are the main infiltrate in lungs of WT mice. Mice devoid of iNKT cells (Jalpha18(-/-) mice) have increased levels of inflammatory monocytes, which correlated with increased lung injury and mortality (but not viral load). Activation of iNKT cells correlated with reduction of MCP-1 levels and improved outcome. iNKT cells were able to selectively lyse infected, MCP-1-producing monocytes in vitro, in a CD1d-dependent process. Our study provides a detailed profile and kinetics of innate immune cells in the lungs during severe IAV infection, highlighting inflammatory monocytes as the major infiltrate and identifying a role for iNKT cells in control of these cells and lung immune-pathology. |Animals[MESH] |Antibodies, Blocking/administration & dosage/immunology[MESH] |Antigens, CD1d/metabolism[MESH] |Antigens, Ly/metabolism[MESH] |Chemokine CCL2/immunology/metabolism[MESH] |Humans[MESH] |Immunophenotyping[MESH] |Inflammation/*immunology/metabolism/pathology[MESH] |Influenza A virus/*immunology[MESH] |Lung/*immunology/metabolism/pathology[MESH] |Lymphocyte Activation/immunology[MESH] |Macrophages/immunology/pathology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Monocytes/*immunology/pathology/virology[MESH] |Natural Killer T-Cells/*immunology[MESH] |Orthomyxoviridae Infections/*immunology/mortality/*pathology[MESH]Pivotal Advance: Invariant NKT cells reduce accumulation of inflammato(epmc).pdf DeepDyve Pubget Overpricing