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10.1038/nature10897 http://scihub22266oqcxt.onion/10.1038/nature10897 22437503!3578422!22437503     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22437503&cmd=llinks): Failed to open stream: HTTP request failed! 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Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy |pdf=|usr=}}{{22437503}} gab.com Text Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=22437503 #FOAvip In pregnancy, trophoblast invasion and uterine spiral artery remodelling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow. Impaired spiral artery remodelling has been implicated in pre-eclampsia, a major complication of pregnancy, for a long time but the underlying mechanisms remain unclear. Corin (also known as atrial natriuretic peptide-converting enzyme) is a cardiac protease that activates atrial natriuretic peptide (ANP), a cardiac hormone that is important in regulating blood pressure. Unexpectedly, corin expression was detected in the pregnant uterus. Here we identify a new function of corin and ANP in promoting trophoblast invasion and spiral artery remodelling. We show that pregnant corin- or ANP-deficient mice developed high blood pressure and proteinuria, characteristics of pre-eclampsia. In these mice, trophoblast invasion and uterine spiral artery remodelling were markedly impaired. Consistent with this, the ANP potently stimulated human trophoblasts in invading Matrigels. In patients with pre-eclampsia, uterine Corin messenger RNA and protein levels were significantly lower than that in normal pregnancies. Moreover, we have identified Corin gene mutations in pre-eclamptic patients, which decreased corin activity in processing pro-ANP. These results indicate that corin and ANP are essential for physiological changes at the maternal-fetal interface, suggesting that defects in corin and ANP function may contribute to pre-eclampsia. Twit Text FOAVip Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=22437503 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22437503 #FOAvip English Wikipedia <ref>{{Cite pmid|22437503}}</ref> Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy #MMPMID22437503 Cui Y; Wang W; Dong N; Lou J; Srinivasan DK; Cheng W; Huang X; Liu M; Fang C; Peng J; Chen S; Wu S; Liu Z; Dong L; Zhou Y; Wu Q Nature 2012[Mar]; 484 (7393): 246-50 PMID22437503show ga In pregnancy, trophoblast invasion and uterine spiral artery remodelling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow. Impaired spiral artery remodelling has been implicated in pre-eclampsia, a major complication of pregnancy, for a long time but the underlying mechanisms remain unclear. Corin (also known as atrial natriuretic peptide-converting enzyme) is a cardiac protease that activates atrial natriuretic peptide (ANP), a cardiac hormone that is important in regulating blood pressure. Unexpectedly, corin expression was detected in the pregnant uterus. Here we identify a new function of corin and ANP in promoting trophoblast invasion and spiral artery remodelling. We show that pregnant corin- or ANP-deficient mice developed high blood pressure and proteinuria, characteristics of pre-eclampsia. In these mice, trophoblast invasion and uterine spiral artery remodelling were markedly impaired. Consistent with this, the ANP potently stimulated human trophoblasts in invading Matrigels. In patients with pre-eclampsia, uterine Corin messenger RNA and protein levels were significantly lower than that in normal pregnancies. Moreover, we have identified Corin gene mutations in pre-eclamptic patients, which decreased corin activity in processing pro-ANP. These results indicate that corin and ANP are essential for physiological changes at the maternal-fetal interface, suggesting that defects in corin and ANP function may contribute to pre-eclampsia. |Animals[MESH] |Atrial Natriuretic Factor/deficiency/genetics/metabolism[MESH] |Blood Pressure/genetics[MESH] |Case-Control Studies[MESH] |Cells, Cultured[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Gene Expression Regulation[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Ischemia/metabolism/pathology[MESH] |Kidney Diseases/genetics/pathology[MESH] |Kidney/blood supply/pathology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Mice, Transgenic[MESH] |Mutation[MESH] |Pre-Eclampsia/genetics/metabolism/pathology/physiopathology[MESH] |Pregnancy[MESH] |Serine Endopeptidases/chemistry/genetics/*metabolism[MESH] |Trophoblasts/*cytology/metabolism[MESH] |Uterine Artery/*growth & development[MESH]Role of corin in trophoblast invasion and uterine spiral artery remode(epmc).pdf DeepDyve Pubget Overpricing