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10.4049/jimmunol.1200660 http://scihub22266oqcxt.onion/10.4049/jimmunol.1200660 22689883!ä!22689883 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22689883&cmd=llinks): Failed to open stream: HTTP request failed! 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Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease |pdf=|usr=}}{{22689883}} gab.com Text Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=22689883 #FOAvip Although great progress has been made in delineating lung dendritic cell and lymphocyte subpopulations, similar advances in lung macrophages (MPhis) have been hampered by their intrinsic autofluorescence, cell plasticity, and the complexities of monocyte-MPhi compartmentalization. Using spectral scanning, we define alveolar MPhi autofluorescence characteristics, which has allowed us to develop an alternative flow cytometry method. Using this methodology, we show that mouse lung MPhis form distinct subpopulations during acute inflammation after challenge with LPS or influenza virus, and in chronic inflammatory lung disease consequent to SHIP-1 deletion. These subpopulations are distinguished by differential Mac-1 and CD11c integrin expression rather than classical M1 or M2 markers, and display differential gene signatures ex vivo. Whereas the resolution of acute inflammation is characterized by restoration to a homogenous population of CD11c(high)Mac-1(neg/low) MPhis reflective of lung homeostasis, chronic inflammatory lung disease associated with SHIP-1 deficiency is accompanied by an additional subpopulation of CD11c(high)Mac-1(pos) MPhis that tracks with lung disease in susceptible genetic background SHIP-1(-/-) animals and disease induction in chimeric mice. These findings may help better understand the roles of MPhi subpopulations in lung homeostasis and disease. Twit Text FOAVip Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=22689883 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22689883 #FOAvip English Wikipedia <ref>{{Cite pmid|22689883}}</ref> Distinct macrophage subpopulations characterize acute infection and chronic inflammatory lung disease #MMPMID22689883 Duan M; Li WC; Vlahos R; Maxwell MJ; Anderson GP; Hibbs ML J Immunol 2012[Jul]; 189 (2): 946-55 PMID22689883show ga Although great progress has been made in delineating lung dendritic cell and lymphocyte subpopulations, similar advances in lung macrophages (MPhis) have been hampered by their intrinsic autofluorescence, cell plasticity, and the complexities of monocyte-MPhi compartmentalization. Using spectral scanning, we define alveolar MPhi autofluorescence characteristics, which has allowed us to develop an alternative flow cytometry method. Using this methodology, we show that mouse lung MPhis form distinct subpopulations during acute inflammation after challenge with LPS or influenza virus, and in chronic inflammatory lung disease consequent to SHIP-1 deletion. These subpopulations are distinguished by differential Mac-1 and CD11c integrin expression rather than classical M1 or M2 markers, and display differential gene signatures ex vivo. Whereas the resolution of acute inflammation is characterized by restoration to a homogenous population of CD11c(high)Mac-1(neg/low) MPhis reflective of lung homeostasis, chronic inflammatory lung disease associated with SHIP-1 deficiency is accompanied by an additional subpopulation of CD11c(high)Mac-1(pos) MPhis that tracks with lung disease in susceptible genetic background SHIP-1(-/-) animals and disease induction in chimeric mice. These findings may help better understand the roles of MPhi subpopulations in lung homeostasis and disease. |Acute Disease[MESH] |Animals[MESH] |Chronic Disease[MESH] |Disease Models, Animal[MESH] |Inflammation/immunology/microbiology/virology[MESH] |Inositol Polyphosphate 5-Phosphatases[MESH] |Macrophages, Alveolar/*immunology/metabolism/*pathology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Mice, Transgenic[MESH] |Orthomyxoviridae Infections/immunology/metabolism/pathology[MESH] |Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases[MESH] |Phosphoric Monoester Hydrolases/physiology[MESH] |Pneumonia, Viral/*immunology/metabolism/*pathology[MESH]Distinct macrophage subpopulations characterize acute infection and ch(epmc).pdf DeepDyve Pubget Overpricing