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10.4414/smw.2012.13613 http://scihub22266oqcxt.onion/10.4414/smw.2012.13613 22802123!ä!22802123 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22802123.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Swiss+Med+Wkly 2012 ; 142 (ä): w13613 Nephropedia Template TP {{tp|p=22802123|t=2012. Physiopathology of hereditary polyuric states: a molecular view of renal function |pdf=|usr=}}{{22802123}} gab.com Text Physiopathology of hereditary polyuric states: a molecular view of renal function JO: Swiss Med Wkly http://www.kidney.de/pget.php?&tw=1&pmid=22802123 #FOAvip Recent discoveries have shed new light on the understanding of water metabolism: (1.) in addition to hypothalamic osmoreceptor cells expressing a TRPV1 variant, there are peripheral TRPV4 receptors sensing tonicity in the portal vein and changing central vasopressin secretion and peripheral autonomic activity; (2.) the central osmoregulatory gain of angiotensin action participates in the non-osmotic release of vasopressin induced by hypovolaemia; (3.) prostaglandins EP2 receptors on principal cells of the collecting ducts positively regulate urine concentration mechanisms. These new developments are important clinically for the understanding of hereditary polyuric states. We recommend sequencing of the nephrogenic diabetes insipidus genes in all affected patients. This genomic information is key to the routine care of patients with congenital polyuria and, as in other genetic diseases, reduces health costs and confers psychological benefits on patients and families. Twit Text FOAVip Physiopathology of hereditary polyuric states: a molecular view of renal function ????Swiss Med Wkly http://www.kidney.de/pget.php?&tw=1&pmid=22802123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22802123 #FOAvip English Wikipedia <ref>{{Cite pmid|22802123}}</ref> Physiopathology of hereditary polyuric states: a molecular view of renal function #MMPMID22802123 Bichet DG Swiss Med Wkly 2012[]; 142 (ä): w13613 PMID22802123show ga Recent discoveries have shed new light on the understanding of water metabolism: (1.) in addition to hypothalamic osmoreceptor cells expressing a TRPV1 variant, there are peripheral TRPV4 receptors sensing tonicity in the portal vein and changing central vasopressin secretion and peripheral autonomic activity; (2.) the central osmoregulatory gain of angiotensin action participates in the non-osmotic release of vasopressin induced by hypovolaemia; (3.) prostaglandins EP2 receptors on principal cells of the collecting ducts positively regulate urine concentration mechanisms. These new developments are important clinically for the understanding of hereditary polyuric states. We recommend sequencing of the nephrogenic diabetes insipidus genes in all affected patients. This genomic information is key to the routine care of patients with congenital polyuria and, as in other genetic diseases, reduces health costs and confers psychological benefits on patients and families. |Arginine Vasopressin/biosynthesis/physiology[MESH] |Diabetes Insipidus/*genetics/physiopathology[MESH] |Humans[MESH] |Kidney/*physiopathology[MESH] |Neurons, Afferent/metabolism[MESH] |Osmolar Concentration[MESH] |Polyuria/genetics/*physiopathology[MESH] |Sodium/blood[MESH] |TRPV Cation Channels/metabolism[MESH]Physiopathology of hereditary polyuric states: a molecular view of ren(epmc).pdf DeepDyve Pubget Overpricing