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10.1021/mp300257x http://scihub22266oqcxt.onion/10.1021/mp300257x 22823162!ä!22823162 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22823162&cmd=llinks): Failed to open stream: HTTP request failed! 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Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice |pdf=|usr=}}{{22823162}} gab.com Text Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice JO: Mol Pharm http://www.kidney.de/pget.php?&tw=1&pmid=22823162 #FOAvip The protective role played by the innate immune system during early stages of infection suggests that compounds which stimulate innate responses could be used as antimicrobial or antiviral agents. In this study, we demonstrate that the Toll-like receptor-2 agonist Pam2Cys, when administered intranasally, triggers a cascade of inflammatory and innate immune signals, acting as an immunostimulant by attracting neutrophils and macrophages and inducing secretion of IL-2, IL-6, IL-10, IFN-gamma, MCP-1 and TNF-alpha. These changes provide increased resistance against influenza A virus challenge and also reduce the potential for transmission of infection. Pam2Cys treatment also reduced weight loss and lethality associated with virulent influenza virus infection in a Toll-like receptor-2-dependent manner. Treatment did not affect the animals' ability to generate an adaptive immune response, measured by the induction of functional influenza A virus-specific CD8(+) T cells following exposure to virus. Because this compound demonstrates efficacy against distinct strains of influenza, it could be a candidate for development as an agent against influenza and possibly other respiratory pathogens. Twit Text FOAVip Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice ????Mol Pharm http://www.kidney.de/pget.php?&tw=1&pmid=22823162 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22823162 #FOAvip English Wikipedia <ref>{{Cite pmid|22823162}}</ref> Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice #MMPMID22823162 Tan AC; Mifsud EJ; Zeng W; Edenborough K; McVernon J; Brown LE; Jackson DC Mol Pharm 2012[Sep]; 9 (9): 2710-8 PMID22823162show ga The protective role played by the innate immune system during early stages of infection suggests that compounds which stimulate innate responses could be used as antimicrobial or antiviral agents. In this study, we demonstrate that the Toll-like receptor-2 agonist Pam2Cys, when administered intranasally, triggers a cascade of inflammatory and innate immune signals, acting as an immunostimulant by attracting neutrophils and macrophages and inducing secretion of IL-2, IL-6, IL-10, IFN-gamma, MCP-1 and TNF-alpha. These changes provide increased resistance against influenza A virus challenge and also reduce the potential for transmission of infection. Pam2Cys treatment also reduced weight loss and lethality associated with virulent influenza virus infection in a Toll-like receptor-2-dependent manner. Treatment did not affect the animals' ability to generate an adaptive immune response, measured by the induction of functional influenza A virus-specific CD8(+) T cells following exposure to virus. Because this compound demonstrates efficacy against distinct strains of influenza, it could be a candidate for development as an agent against influenza and possibly other respiratory pathogens. |Adaptive Immunity/drug effects/immunology[MESH] |Administration, Intranasal[MESH] |Animals[MESH] |Antiviral Agents/immunology[MESH] |CD8-Positive T-Lymphocytes/drug effects/immunology[MESH] |Chemokine CCL2/immunology[MESH] |Female[MESH] |Immunity, Innate/drug effects/immunology[MESH] |Inflammation/immunology[MESH] |Influenza A virus/*drug effects/immunology[MESH] |Interferon-gamma/immunology[MESH] |Interleukins/immunology[MESH] |Lipopeptides/*administration & dosage/immunology[MESH] |Lung/drug effects/immunology[MESH] |Macrophages/drug effects/immunology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Mice, Transgenic[MESH] |Neutrophils/drug effects/immunology[MESH] |Orthomyxoviridae Infections/immunology/*prevention & control[MESH] |Toll-Like Receptor 2/*agonists[MESH]Intranasal administration of the TLR2 agonist Pam2Cys provides rapid p(epmc).pdf DeepDyve Pubget Overpricing