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10.1681/ASN.2012030240 http://scihub22266oqcxt.onion/10.1681/ASN.2012030240 22956818!3458464!22956818     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22956818.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Nephrol 2012 ; 23 (10): 1744-52 Nephropedia Template TP {{tp|p=22956818|t=2012. Nanoparticle-based test measures overall propensity for calcification in serum |pdf=|usr=}}{{22956818}} gab.com Text Nanoparticle-based test measures overall propensity for calcification in serum JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=22956818 #FOAvip Vascular and soft tissue calcification contributes to cardiovascular morbidity and mortality in both the general population and CKD. Because calcium and phosphate serum concentrations are near supersaturation, the balance of inhibitors and promoters critically influences the development of calcification. An assay that measures the overall propensity for calcification to occur in serum may have clinical use. Here, we describe a nanoparticle-based assay that detects, in the presence of artificially elevated calcium and phosphate concentrations, the spontaneous transformation of spherical colloidal primary calciprotein particles (CPPs) to elongate crystalline secondary CPPs. We used characteristics of this transition to describe the intrinsic capacity of serum to inhibit the precipitation of calcium and phosphate. Using this assay, we found that both the sera of mice deficient in fetuin-A, a serum protein that inhibits calcification, and the sera of patients on hemodialysis have reduced intrinsic properties to inhibit calcification. In summary, we developed a nanoparticle-based test that measures the overall propensity for calcification in serum. The clinical use of the test requires evaluation in a prospective study. Twit Text FOAVip Nanoparticle-based test measures overall propensity for calcification in serum ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=22956818 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22956818 #FOAvip English Wikipedia <ref>{{Cite pmid|22956818}}</ref> Nanoparticle-based test measures overall propensity for calcification in serum #MMPMID22956818 Pasch A; Farese S; Graber S; Wald J; Richtering W; Floege J; Jahnen-Dechent W J Am Soc Nephrol 2012[Oct]; 23 (10): 1744-52 PMID22956818show ga Vascular and soft tissue calcification contributes to cardiovascular morbidity and mortality in both the general population and CKD. Because calcium and phosphate serum concentrations are near supersaturation, the balance of inhibitors and promoters critically influences the development of calcification. An assay that measures the overall propensity for calcification to occur in serum may have clinical use. Here, we describe a nanoparticle-based assay that detects, in the presence of artificially elevated calcium and phosphate concentrations, the spontaneous transformation of spherical colloidal primary calciprotein particles (CPPs) to elongate crystalline secondary CPPs. We used characteristics of this transition to describe the intrinsic capacity of serum to inhibit the precipitation of calcium and phosphate. Using this assay, we found that both the sera of mice deficient in fetuin-A, a serum protein that inhibits calcification, and the sera of patients on hemodialysis have reduced intrinsic properties to inhibit calcification. In summary, we developed a nanoparticle-based test that measures the overall propensity for calcification in serum. The clinical use of the test requires evaluation in a prospective study. |*Nanoparticles[MESH] |Animals[MESH] |Calcinosis/*blood[MESH] |Calcium/*blood[MESH] |Case-Control Studies[MESH] |Chemical Precipitation[MESH] |Colloids[MESH] |Crystallization[MESH] |Humans[MESH] |Light[MESH] |Mice[MESH] |Mice, Inbred DBA[MESH] |Mice, Knockout[MESH] |Nanotechnology/*methods[MESH] |Nephelometry and Turbidimetry[MESH] |Phosphates/blood[MESH] |Renal Dialysis[MESH] |Scattering, Radiation[MESH] |Solubility[MESH]Nanoparticle-based test measures overall propensity for calcification (epmc).pdf DeepDyve Pubget Overpricing