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10.1152/ajplung.00072.2013 http://scihub22266oqcxt.onion/10.1152/ajplung.00072.2013 23709618!3726950!23709618     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23709618.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Lung+Cell+Mol+Physiol 2013 ; 305 (2): L93-107 Nephropedia Template TP {{tp|p=23709618|t=2013. Autophagy: a potential therapeutic target in lung diseases |pdf=|usr=}}{{23709618}} gab.com Text Autophagy: a potential therapeutic target in lung diseases JO: Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23709618 #FOAvip Macroautophagy (hereafter referred to as autophagy) is an evolutionally conserved intracellular process to maintain cellular homeostasis by facilitating the turnover of protein aggregates, cellular debris, and damaged organelles. During autophagy, cytosolic constituents are engulfed into double-membrane-bound vesicles called "autophagosomes," which are subsequently delivered to the lysosome for degradation. Accumulated evidence suggests that autophagy is critically involved not only in the basal physiological states but also in the pathogenesis of various human diseases. Interestingly, a diverse variety of clinically approved drugs modulate autophagy to varying extents, although they are not currently utilized for the therapeutic purpose of manipulating autophagy. In this review, we highlight the functional roles of autophagy in lung diseases with focus on the recent progress of the potential therapeutic use of autophagy-modifying drugs in clinical medicine. The purpose of this review is to discuss the merits, and the pitfalls, of modulating autophagy as a therapeutic strategy in lung diseases. Twit Text FOAVip Autophagy: a potential therapeutic target in lung diseases ????Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23709618 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23709618 #FOAvip English Wikipedia <ref>{{Cite pmid|23709618}}</ref> Autophagy: a potential therapeutic target in lung diseases #MMPMID23709618 Nakahira K; Choi AM Am J Physiol Lung Cell Mol Physiol 2013[Jul]; 305 (2): L93-107 PMID23709618show ga Macroautophagy (hereafter referred to as autophagy) is an evolutionally conserved intracellular process to maintain cellular homeostasis by facilitating the turnover of protein aggregates, cellular debris, and damaged organelles. During autophagy, cytosolic constituents are engulfed into double-membrane-bound vesicles called "autophagosomes," which are subsequently delivered to the lysosome for degradation. Accumulated evidence suggests that autophagy is critically involved not only in the basal physiological states but also in the pathogenesis of various human diseases. Interestingly, a diverse variety of clinically approved drugs modulate autophagy to varying extents, although they are not currently utilized for the therapeutic purpose of manipulating autophagy. In this review, we highlight the functional roles of autophagy in lung diseases with focus on the recent progress of the potential therapeutic use of autophagy-modifying drugs in clinical medicine. The purpose of this review is to discuss the merits, and the pitfalls, of modulating autophagy as a therapeutic strategy in lung diseases. |*Autophagy[MESH] |Animals[MESH] |Cell-Derived Microparticles/metabolism[MESH] |Humans[MESH] |Lung Diseases/*metabolism/*therapy[MESH]Autophagy: a potential therapeutic target in lung diseases (epmc).pdf DeepDyve Pubget Overpricing