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10.3109/10641955.2013.810237

http://scihub22266oqcxt.onion/10.3109/10641955.2013.810237
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23844728!ä!23844728

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suck abstract from ncbi


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pmid23844728      Hypertens+Pregnancy 2013 ; 32 (4): 378-89
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  • SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women #MMPMID23844728
  • Kolisek M; Galaviz-Hernandez C; Vazquez-Alaniz F; Sponder G; Javaid S; Kurth K; Nestler A; Rodriguez-Moran M; Verlohren S; Guerrero-Romero F; Aschenbach JR; Vormann J
  • Hypertens Pregnancy 2013[Nov]; 32 (4): 378-89 PMID23844728show ga
  • OBJECTIVE: To examine expression profile of magnesium responsive genes (MRGs) in placentas of normoevolutive and preeclamptic women. METHODS: The expression profiles of MRGs were determined in placentas of normoevolutive (N=26) and preeclamptic (N=25) women by RT-qPCR. RESULTS: Among all tested MRGs (9) only SLC41A1 (encoding for Na(+)/Mg(2+) exchanger) was significantly overexpressed in ~54.2% of preeclamptic (n=24) and in ~9.5% of normoevolutive (n=21) specimens. On average, SLC41A1 was overexpressed sixfold in the preeclamptic group. Presence of SLC41A1 in placentas was confirmed by Western blot analysis. CONCLUSION. SLC41A1 is significantly overexpressed in nearly 55% of preeclamptic placentas. This may indicate a direct contribution of changed Mg homeostasis in the development of preeclampsia.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Case-Control Studies[MESH]
  • |Cation Transport Proteins/*metabolism[MESH]
  • |Female[MESH]
  • |Gene Expression Regulation[MESH]
  • |Humans[MESH]
  • |Magnesium/*metabolism[MESH]
  • |Placenta/*metabolism[MESH]
  • |Pre-Eclampsia/*metabolism[MESH]
  • |Pregnancy[MESH]


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