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10.1183/09059180.00001713 http://scihub22266oqcxt.onion/10.1183/09059180.00001713 23997048!9487345!23997048     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23997048&cmd=llinks): Failed to open stream: HTTP request failed! 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Therapies for pulmonary arterial hypertension: where are we today, where do we go tomorrow?|pdf=|usr=}}{{23997048}} gab.com Text Therapies for pulmonary arterial hypertension: where are we today, where do we go tomorrow JO: Eur Respir Rev http://www.kidney.de/pget.php?&tw=1&pmid=23997048 #FOAvip Pulmonary arterial hypertension (PAH) is a progressive disease characterised by remodelling of small pulmonary arteries leading to an increased pulmonary vascular resistance, right ventricular failure and death. Available treatments try to re-establish the equilibrium on three signalling pathways: the prostacyclin, the endothelin (ET)-1 and the nitric oxide. Prostanoids, such as epoprostenol or treprostinil have a vasodilator, antiproliferative and immunomodulatory effect and, despite the administration inconveniences, represent established therapies for severe cases of PAH. Recently oral prostacyclin receptor agonists have shown encouraging results. Many clinical studies targeting the vasoconstrictor ET-1 pathway with receptor antagonists like bosentan and ambrisentan have shown strong results, even more optimism coming from macitentan, the newest drug. Sildenafil and tadalafil, two phosphodiesterase type-5 inhibitors, have shown improved exercise capacity by increasing the nitric oxide level. Riociguat, acting on the same nitric oxide pathway, as a guanylatecyclase activator, has shown promising results in clinical trials and will be available soon. Long-awaited results for tyrosin-kinase inhibitor, imatinib, as an antiproliferative therapy in PAH have been disappointing, due to severe adverse events. In conclusion, although it remains a disease with severe prognosis, the past 20 years have represented a huge progress in terms of treatments for PAH with interesting opportunities for the future. Twit Text FOAVip Therapies for pulmonary arterial hypertension: where are we today, where do we go tomorrow ????Eur Respir Rev http://www.kidney.de/pget.php?&tw=1&pmid=23997048 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23997048 #FOAvip English Wikipedia <ref>{{Cite pmid|23997048}}</ref> Therapies for pulmonary arterial hypertension: where are we today, where do we go tomorrow? #MMPMID23997048 Seferian A; Simonneau G Eur Respir Rev 2013[Sep]; 22 (129): 217-26 PMID23997048show ga Pulmonary arterial hypertension (PAH) is a progressive disease characterised by remodelling of small pulmonary arteries leading to an increased pulmonary vascular resistance, right ventricular failure and death. Available treatments try to re-establish the equilibrium on three signalling pathways: the prostacyclin, the endothelin (ET)-1 and the nitric oxide. Prostanoids, such as epoprostenol or treprostinil have a vasodilator, antiproliferative and immunomodulatory effect and, despite the administration inconveniences, represent established therapies for severe cases of PAH. Recently oral prostacyclin receptor agonists have shown encouraging results. Many clinical studies targeting the vasoconstrictor ET-1 pathway with receptor antagonists like bosentan and ambrisentan have shown strong results, even more optimism coming from macitentan, the newest drug. Sildenafil and tadalafil, two phosphodiesterase type-5 inhibitors, have shown improved exercise capacity by increasing the nitric oxide level. Riociguat, acting on the same nitric oxide pathway, as a guanylatecyclase activator, has shown promising results in clinical trials and will be available soon. Long-awaited results for tyrosin-kinase inhibitor, imatinib, as an antiproliferative therapy in PAH have been disappointing, due to severe adverse events. In conclusion, although it remains a disease with severe prognosis, the past 20 years have represented a huge progress in terms of treatments for PAH with interesting opportunities for the future. |Animals[MESH] |Antihypertensive Agents/adverse effects/*therapeutic use[MESH] |Arterial Pressure/*drug effects[MESH] |Familial Primary Pulmonary Hypertension[MESH] |Humans[MESH] |Hypertension, Pulmonary/diagnosis/*drug therapy/metabolism/physiopathology[MESH] |Pulmonary Artery/*drug effects/metabolism/physiopathology[MESH] |Signal Transduction/drug effects[MESH]Therapies for pulmonary arterial hypertension: where are we today, whe(epmc).pdf DeepDyve Pubget Overpricing