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10.1016/j.ajpath.2013.07.034 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2013.07.034 24055371!�!24055371 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24055371&cmd=llinks): Failed to open stream: HTTP request failed! 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Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties |pdf=|usr=}}{{24055371}} gab.com Text Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=24055371 #FOAvip The nephron is composed of a monolayer of epithelial cells that make up its various compartments. In development, these cells begin as mesenchyme. NCAM1, abundant in the mesenchyme and early nephron lineage, ceases to express in mature kidney epithelia. We show that, once placed in culture and released from quiescence, adult human kidney epithelial cells (hKEpCs), uniformly positive for CD24/CD133, re-express NCAM1 in a specific cell subset that attains a stem/progenitor state. Immunosorted NCAM1(+) cells overexpressed early nephron progenitor markers (PAX2, SALL1, SIX2, WT1) and acquired a mesenchymal fate, indicated by high vimentim and reduced E-cadherin levels. Gene expression and microarray analysis disclosed both a proximal tubular origin of these cells and molecules regulating epithelial-mesenchymal transition. NCAM1(+) cells generated clonal progeny when cultured in the presence of fetal kidney conditioned medium, differentiated along mesenchymal lineages but retained the unique propensity to generate epithelial kidney spheres and produce epithelial renal tissue on single-cell grafting in chick CAM and mouse. Depletion of NCAM1(+) cells from hKEpCs abrogated stemness traits in vitro. Eliminating these cells during the regenerative response that follows glycerol-induced acute tubular necrosis worsened peak renal injury in vivo. Thus, higher clone-forming and developmental capacities characterize a distinct subset of adult kidney-derived cells. The ability to influence an endogenous regenerative response via NCAM1 targeting may lead to novel therapeutics for renal diseases. Twit Text FOAVip Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=24055371 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24055371 #FOAvip English Wikipedia <ref>{{Cite pmid|24055371}}</ref> Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties #MMPMID24055371 Buzhor E; Omer D; Harari-Steinberg O; Dotan Z; Vax E; Pri-Chen S; Metsuyanim S; Pleniceanu O; Goldstein RS; Dekel B Am J Pathol 2013[Nov]; 183 (5): 1621-1633 PMID24055371show ga The nephron is composed of a monolayer of epithelial cells that make up its various compartments. In development, these cells begin as mesenchyme. NCAM1, abundant in the mesenchyme and early nephron lineage, ceases to express in mature kidney epithelia. We show that, once placed in culture and released from quiescence, adult human kidney epithelial cells (hKEpCs), uniformly positive for CD24/CD133, re-express NCAM1 in a specific cell subset that attains a stem/progenitor state. Immunosorted NCAM1(+) cells overexpressed early nephron progenitor markers (PAX2, SALL1, SIX2, WT1) and acquired a mesenchymal fate, indicated by high vimentim and reduced E-cadherin levels. Gene expression and microarray analysis disclosed both a proximal tubular origin of these cells and molecules regulating epithelial-mesenchymal transition. NCAM1(+) cells generated clonal progeny when cultured in the presence of fetal kidney conditioned medium, differentiated along mesenchymal lineages but retained the unique propensity to generate epithelial kidney spheres and produce epithelial renal tissue on single-cell grafting in chick CAM and mouse. Depletion of NCAM1(+) cells from hKEpCs abrogated stemness traits in vitro. Eliminating these cells during the regenerative response that follows glycerol-induced acute tubular necrosis worsened peak renal injury in vivo. Thus, higher clone-forming and developmental capacities characterize a distinct subset of adult kidney-derived cells. The ability to influence an endogenous regenerative response via NCAM1 targeting may lead to novel therapeutics for renal diseases. |Acute Kidney Injury/metabolism/pathology[MESH] |Adult[MESH] |Animals[MESH] |Antibodies/metabolism[MESH] |Biomarkers/metabolism[MESH] |Blood Urea Nitrogen[MESH] |CD56 Antigen/*metabolism[MESH] |Cell Differentiation/genetics[MESH] |Cell Proliferation[MESH] |Chickens[MESH] |Clone Cells[MESH] |Down-Regulation/genetics[MESH] |Epithelial Cells/*metabolism/*pathology[MESH] |Gene Ontology[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Kidney/*pathology[MESH] |Mesoderm/pathology[MESH] |Mice[MESH] |Molecular Sequence Annotation[MESH] |Nephrons/metabolism/pathology[MESH] |Oligonucleotide Array Sequence Analysis[MESH] |Spheroids, Cellular/metabolism/pathology[MESH] |Stem Cells/*metabolism[MESH] |Transcriptome/genetics[MESH]Reactivation of NCAM1 defines a subpopulation of human adult kidney ep(epmc).pdf DeepDyve Pubget Overpricing