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Human parvovirus B19 infection leads to downregulation of thyroid, estrogen, and retinoid hormone receptor expression #MMPMID24074579
Ignatovich IV; Hobbs JA
Virology 2013[Nov]; 446 (1-2): 173-9 PMID24074579show ga
Erythrovirus B19 (B19V) is a member of the family Parvoviridae. Infection with B19V has been linked to a variety of diseases including erythroid, thyroid, neurological and autoimmune diseases. Here we show that infection of primary CD36+ cells with B19V coincides with downregulation of thyroid, retinoid, and estrogen hormone receptors. In addition we show changes in expression of a variety of related downstream signaling genes participating in cancer and cardiac-related diseases in B19V-infected erythroid primary cells.