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10.1016/j.transproceed.2013.10.036 http://scihub22266oqcxt.onion/10.1016/j.transproceed.2013.10.036 24507022!ä!24507022 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24507022&cmd=llinks): Failed to open stream: HTTP request failed! 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Effect of verapamil and lidocaine on TRPM and NaV1 9 gene expressions in renal ischemia-reperfusion |pdf=|usr=}}{{24507022}} gab.com Text Effect of verapamil and lidocaine on TRPM and NaV1 9 gene expressions in renal ischemia-reperfusion JO: Transplant Proc http://www.kidney.de/pget.php?&tw=1&pmid=24507022 #FOAvip BACKGROUND: To determine effects on calcium and sodium channels of Ca(2+) and Na(+) channel blockers in the present study, expression levels of TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, and NaV1.9 genes were evaluated in kidney tissues after induced ischemia-reperfusion. MATERIAL AND METHODS: Forty albino Wistar male rats were equally divided into 4 groups as follows: group I: control group (n = 10), group II: ischemia group (60 minutes of ischemia + 48 hours of reperfusion; n = 10), group III: ischemia (60 minutes of ischemia + 48 hours of reperfusion) + calcium channel blocker (n = 8), group IV: ischemia (60 minutes of ischemia + 48 hours of reperfusion) + sodium channel blocker (n = 8). RESULTS: When compared to ischemia group expression levels of TRPM2, TRPM4, TRPM6, and NaV1.9 in Ca(2+) and Na(+) channel blocker groups were increased, whereas that of TRPM7 was decreased. However, expression levels of TRPM1, TRPM3, TRPM5, and TRPM8 were not determined in kidney tissue. Histologically, the Ca(2+) channel blocker verapamil and the Na(+) channel blocker lidocaine inhibited the cell death in kidney tissue compared to control. CONCLUSION: Our study suggested that verapamil and lidocaine significantly reduce the degree of ischemia-reperfusion injury due to effects to TRPM and Nav1.9 genes. Twit Text FOAVip Effect of verapamil and lidocaine on TRPM and NaV1 9 gene expressions in renal ischemia-reperfusion ????Transplant Proc http://www.kidney.de/pget.php?&tw=1&pmid=24507022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24507022 #FOAvip English Wikipedia <ref>{{Cite pmid|24507022}}</ref> Effect of verapamil and lidocaine on TRPM and NaV1 9 gene expressions in renal ischemia-reperfusion #MMPMID24507022 Dusmez D; Cengiz B; Yumrutas O; Demir T; Oztuzcu S; Demiryurek S; Tutar E; Bayraktar R; Bulut A; Simsek H; Dagli SN; Kilic T; Bagci C Transplant Proc 2014[Jan]; 46 (1): 33-9 PMID24507022show ga BACKGROUND: To determine effects on calcium and sodium channels of Ca(2+) and Na(+) channel blockers in the present study, expression levels of TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, and NaV1.9 genes were evaluated in kidney tissues after induced ischemia-reperfusion. MATERIAL AND METHODS: Forty albino Wistar male rats were equally divided into 4 groups as follows: group I: control group (n = 10), group II: ischemia group (60 minutes of ischemia + 48 hours of reperfusion; n = 10), group III: ischemia (60 minutes of ischemia + 48 hours of reperfusion) + calcium channel blocker (n = 8), group IV: ischemia (60 minutes of ischemia + 48 hours of reperfusion) + sodium channel blocker (n = 8). RESULTS: When compared to ischemia group expression levels of TRPM2, TRPM4, TRPM6, and NaV1.9 in Ca(2+) and Na(+) channel blocker groups were increased, whereas that of TRPM7 was decreased. However, expression levels of TRPM1, TRPM3, TRPM5, and TRPM8 were not determined in kidney tissue. Histologically, the Ca(2+) channel blocker verapamil and the Na(+) channel blocker lidocaine inhibited the cell death in kidney tissue compared to control. CONCLUSION: Our study suggested that verapamil and lidocaine significantly reduce the degree of ischemia-reperfusion injury due to effects to TRPM and Nav1.9 genes. |*Gene Expression Regulation[MESH] |Animals[MESH] |Calcium Channel Blockers/*administration & dosage[MESH] |Calcium Channels/metabolism[MESH] |Disease Models, Animal[MESH] |Kidney Diseases/*drug therapy/*pathology[MESH] |Kidney/*pathology[MESH] |Lidocaine/*administration & dosage[MESH] |Male[MESH] |NAV1.9 Voltage-Gated Sodium Channel/*metabolism[MESH] |Rats[MESH] |Rats, Wistar[MESH] |Reperfusion Injury/*drug therapy[MESH] |TRPM Cation Channels/*metabolism[MESH] |Verapamil/*administration & dosage[MESH]Effect of verapamil and lidocaine on TRPM and NaV1 9 gene expressions (epmc).pdf DeepDyve Pubget Overpricing