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Influence of lactuside B on the expression of AQP4 and TRPM7 mRNAs in the cerebral cortex after cerebral ischemia injury |pdf=|usr=}}{{24817288}} gab.com Text Influence of lactuside B on the expression of AQP4 and TRPM7 mRNAs in the cerebral cortex after cerebral ischemia injury JO: Eur Rev Med Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=24817288 #FOAvip AIM: This study aimed to determine the effect of Lactuside B isolated from Pterocypsela alata on the expression of AQP4 and TRPM7 mRNAs after cerebral ischemic injury. MATERIALS AND METHODS: Brain ischemia injury was established by occluding the MCA (middle cerebral artery) for 2 h, followed by reperfusion in rats. The neurologic deficit scores were used to determine the success of the model. All drugs were intraperitoneally administered once a day (5 ml/kg). Eight animals from each group were investigated for the Na+ level, and the others were examined for AQP4 and TRPM7 mRNA changes. RESULTS: Compared with the model group, the neurologic deficit scores and Na+ levels decreased in the lactuside B groups (p < 0.05 vs. p < 0.01). All lactuside B groups had significantly decreased AQP4 and TRPM7 mRNA expression compared with the model group (p < 0.05 vs. < 0.01). Dose dependence was observed between low and medium doses. CONCLUSIONS: Lactuside B protected against cerebral edema and nerve cell damage caused by cerebral ischemic injury by decreasing the expression of AQP4 and TRPM7 mRNAs in the cerebral cortex of rats. Twit Text FOAVip Influence of lactuside B on the expression of AQP4 and TRPM7 mRNAs in the cerebral cortex after cerebral ischemia injury ????Eur Rev Med Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=24817288 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24817288 #FOAvip English Wikipedia <ref>{{Cite pmid|24817288}}</ref> Influence of lactuside B on the expression of AQP4 and TRPM7 mRNAs in the cerebral cortex after cerebral ischemia injury #MMPMID24817288 Zhan HQ; Li PF; Li SY; Yan FL; Yang J; Liu RL; Zhang HF Eur Rev Med Pharmacol Sci 2014[]; 18 (8): 1151-7 PMID24817288show ga AIM: This study aimed to determine the effect of Lactuside B isolated from Pterocypsela alata on the expression of AQP4 and TRPM7 mRNAs after cerebral ischemic injury. MATERIALS AND METHODS: Brain ischemia injury was established by occluding the MCA (middle cerebral artery) for 2 h, followed by reperfusion in rats. The neurologic deficit scores were used to determine the success of the model. All drugs were intraperitoneally administered once a day (5 ml/kg). Eight animals from each group were investigated for the Na+ level, and the others were examined for AQP4 and TRPM7 mRNA changes. RESULTS: Compared with the model group, the neurologic deficit scores and Na+ levels decreased in the lactuside B groups (p < 0.05 vs. p < 0.01). All lactuside B groups had significantly decreased AQP4 and TRPM7 mRNA expression compared with the model group (p < 0.05 vs. < 0.01). Dose dependence was observed between low and medium doses. CONCLUSIONS: Lactuside B protected against cerebral edema and nerve cell damage caused by cerebral ischemic injury by decreasing the expression of AQP4 and TRPM7 mRNAs in the cerebral cortex of rats. |Animals[MESH] |Aquaporin 4/*genetics[MESH] |Brain Edema/genetics/metabolism/prevention & control[MESH] |Cerebral Cortex/*drug effects/metabolism/pathology[MESH] |Cytoprotection[MESH] |Disease Models, Animal[MESH] |Dose-Response Relationship, Drug[MESH] |Down-Regulation[MESH] |Drug Administration Schedule[MESH] |Glucosides/administration & dosage/*pharmacology[MESH] |Infarction, Middle Cerebral Artery/*drug therapy/genetics/metabolism/pathology[MESH] |Injections, Intraperitoneal[MESH] |Male[MESH] |Neuroprotective Agents/administration & dosage/*pharmacology[MESH] |RNA, Messenger/*metabolism[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Sodium/metabolism[MESH] |TRPM Cation Channels/*genetics[MESH]Influence of lactuside B on the expression of AQP4 and TRPM7 mRNAs in (epmc).pdf DeepDyve Pubget Overpricing