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10.1084/jem.20131092 http://scihub22266oqcxt.onion/10.1084/jem.20131092 24889201!4076588!24889201     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24889201&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24889201.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2014 ; 211 (7): 1485-97 Nephropedia Template TP {{tp|p=24889201|t=2014. beta2 integrin mediates hantavirus-induced release of neutrophil extracellular traps |pdf=|usr=}}{{24889201}} gab.com Text beta2 integrin mediates hantavirus-induced release of neutrophil extracellular traps JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=24889201 #FOAvip Rodent-borne hantaviruses are emerging human pathogens that cause severe human disease. The underlying mechanisms are not well understood, as hantaviruses replicate in endothelial and epithelial cells without causing any cytopathic effect. We demonstrate that hantaviruses strongly stimulated neutrophils to release neutrophil extracellular traps (NETs). Hantavirus infection induced high systemic levels of circulating NETs in patients and this systemic NET overflow was accompanied by production of autoantibodies to nuclear antigens. Analysis of the responsible mechanism using neutrophils from beta2 null mice identified beta2 integrin receptors as a master switch for NET induction. Further experiments suggested that beta2 integrin receptors such as complement receptor 3 (CR3) and 4 (CR4) may act as novel hantavirus entry receptors. Using adenoviruses, we confirmed that viral interaction with beta2 integrin induced strong NET formation. Collectively, beta2 integrin-mediated systemic NET overflow is a novel viral mechanism of immunopathology that may be responsible for characteristic aspects of hantavirus-associated disease such as kidney and lung damage. Twit Text FOAVip beta2 integrin mediates hantavirus-induced release of neutrophil extracellular traps ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=24889201 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24889201 #FOAvip English Wikipedia <ref>{{Cite pmid|24889201}}</ref> beta2 integrin mediates hantavirus-induced release of neutrophil extracellular traps #MMPMID24889201 Raftery MJ; Lalwani P; Krautkr?mer E; Peters T; Scharffetter-Kochanek K; Kruger R; Hofmann J; Seeger K; Kruger DH; Schonrich G J Exp Med 2014[Jun]; 211 (7): 1485-97 PMID24889201show ga Rodent-borne hantaviruses are emerging human pathogens that cause severe human disease. The underlying mechanisms are not well understood, as hantaviruses replicate in endothelial and epithelial cells without causing any cytopathic effect. We demonstrate that hantaviruses strongly stimulated neutrophils to release neutrophil extracellular traps (NETs). Hantavirus infection induced high systemic levels of circulating NETs in patients and this systemic NET overflow was accompanied by production of autoantibodies to nuclear antigens. Analysis of the responsible mechanism using neutrophils from beta2 null mice identified beta2 integrin receptors as a master switch for NET induction. Further experiments suggested that beta2 integrin receptors such as complement receptor 3 (CR3) and 4 (CR4) may act as novel hantavirus entry receptors. Using adenoviruses, we confirmed that viral interaction with beta2 integrin induced strong NET formation. Collectively, beta2 integrin-mediated systemic NET overflow is a novel viral mechanism of immunopathology that may be responsible for characteristic aspects of hantavirus-associated disease such as kidney and lung damage. |Adenoviridae[MESH] |Animals[MESH] |Autoantibodies/genetics/immunology[MESH] |CD18 Antigens/genetics/*immunology[MESH] |CHO Cells[MESH] |Cricetinae[MESH] |Cricetulus[MESH] |Female[MESH] |Hantavirus Infections/genetics/*immunology/pathology[MESH] |Humans[MESH] |Integrin alphaXbeta2/genetics/immunology[MESH] |Kidney Diseases/genetics/immunology/pathology/virology[MESH] |Lung Diseases/genetics/immunology/pathology/virology[MESH] |Macrophage-1 Antigen/genetics/immunology[MESH] |Male[MESH] |Mice[MESH] |Mice, Mutant Strains[MESH] |Neutrophils/*immunology/pathology[MESH]beta2 integrin mediates hantavirus-induced release of neutrophil extra(epmc).pdf DeepDyve Pubget Overpricing