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10.1111/bph.12792 http://scihub22266oqcxt.onion/10.1111/bph.12792 24902607!4209143!24902607     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24902607&cmd=llinks): Failed to open stream: HTTP request failed! 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Pharmacological regulators of autophagy and their link with modulators of lupus disease |pdf=|usr=}}{{24902607}} gab.com Text Pharmacological regulators of autophagy and their link with modulators of lupus disease JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24902607 #FOAvip Autophagy is a central regulator of cell survival. It displays both anti- and pro-death roles that are decisive in the maintenance of cell homeostasis. Initially described in several eukaryotic cellular models as being induced under nutrient stress favouring survival by energy supply, autophagy was found later to display other decisive physiological roles, especially in the immune system. Thus, it is involved in antigen presentation and lymphocyte differentiation as well as in the balance regulating survival/death and activation of lymphocytes. Autophagy therefore appears to be central in the regulation of inflammation. The observation that autophagy is deregulated in systemic lupus erythematosus is recent. This discovery revives the programme dealing with the design and development of pharmacological autophagy regulators in the therapeutic context of lupus, a debilitating autoimmune disease that affects several million people in the world. A large number of molecules that positively and negatively regulate autophagy have been described, most of them with therapeutic indications in cancer and infection. Only a few, however, are effectively potent activators or inhibitors endowed with experimentally demonstrated selective properties. In this review article, we highlight the most relevant ones and summarize what we know regarding their mechanism of action. We emphasize the link between pharmacological regulators of autophagy and inducers or inhibitors of lupus disease and discuss the fundamental and pharmacological/therapeutic interest of this functional interplay. Twit Text FOAVip Pharmacological regulators of autophagy and their link with modulators of lupus disease ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24902607 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24902607 #FOAvip English Wikipedia <ref>{{Cite pmid|24902607}}</ref> Pharmacological regulators of autophagy and their link with modulators of lupus disease #MMPMID24902607 Gros F; Muller S Br J Pharmacol 2014[Oct]; 171 (19): 4337-59 PMID24902607show ga Autophagy is a central regulator of cell survival. It displays both anti- and pro-death roles that are decisive in the maintenance of cell homeostasis. Initially described in several eukaryotic cellular models as being induced under nutrient stress favouring survival by energy supply, autophagy was found later to display other decisive physiological roles, especially in the immune system. Thus, it is involved in antigen presentation and lymphocyte differentiation as well as in the balance regulating survival/death and activation of lymphocytes. Autophagy therefore appears to be central in the regulation of inflammation. The observation that autophagy is deregulated in systemic lupus erythematosus is recent. This discovery revives the programme dealing with the design and development of pharmacological autophagy regulators in the therapeutic context of lupus, a debilitating autoimmune disease that affects several million people in the world. A large number of molecules that positively and negatively regulate autophagy have been described, most of them with therapeutic indications in cancer and infection. Only a few, however, are effectively potent activators or inhibitors endowed with experimentally demonstrated selective properties. In this review article, we highlight the most relevant ones and summarize what we know regarding their mechanism of action. We emphasize the link between pharmacological regulators of autophagy and inducers or inhibitors of lupus disease and discuss the fundamental and pharmacological/therapeutic interest of this functional interplay. |*Autophagy[MESH] |*Lupus Erythematosus, Systemic/immunology/physiopathology[MESH] |Animals[MESH] |Autoimmunity[MESH] |Humans[MESH]Pharmacological regulators of autophagy and their link with modulators(epmc).pdf DeepDyve Pubget Overpricing