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10.1111/bph.12829 http://scihub22266oqcxt.onion/10.1111/bph.12829 24977655!4253453!24977655     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24977655.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Pharmacol 2014 ; 171 (22): 5011-31 Nephropedia Template TP {{tp|p=24977655|t=2014. Therapeutic interventions in sepsis: current and anticipated pharmacological agents |pdf=|usr=}}{{24977655}} gab.com Text Therapeutic interventions in sepsis: current and anticipated pharmacological agents JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24977655 #FOAvip Sepsis is a clinical syndrome characterized by a multisystem response to a pathogenic assault due to underlying infection that involves a combination of interconnected biochemical, cellular and organ-organ interactive networks. After the withdrawal of recombinant human-activated protein C (rAPC), researchers and physicians have continued to search for new therapeutic approaches and targets against sepsis, effective in both hypo- and hyperinflammatory states. Currently, statins are being evaluated as a viable option in clinical trials. Many agents that have shown favourable results in experimental sepsis are not clinically effective or have not been clinically evaluated. Apart from developing new therapeutic molecules, there is great scope for for developing a variety of drug delivery strategies, such as nanoparticulate carriers and phospholipid-based systems. These nanoparticulate carriers neutralize intracorporeal LPS as well as deliver therapeutic agents to targeted tissues and subcellular locations. Here, we review and critically discuss the present status and new experimental and clinical approaches for therapeutic intervention in sepsis. Twit Text FOAVip Therapeutic interventions in sepsis: current and anticipated pharmacological agents ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24977655 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24977655 #FOAvip English Wikipedia <ref>{{Cite pmid|24977655}}</ref> Therapeutic interventions in sepsis: current and anticipated pharmacological agents #MMPMID24977655 Shukla P; Rao GM; Pandey G; Sharma S; Mittapelly N; Shegokar R; Mishra PR Br J Pharmacol 2014[Nov]; 171 (22): 5011-31 PMID24977655show ga Sepsis is a clinical syndrome characterized by a multisystem response to a pathogenic assault due to underlying infection that involves a combination of interconnected biochemical, cellular and organ-organ interactive networks. After the withdrawal of recombinant human-activated protein C (rAPC), researchers and physicians have continued to search for new therapeutic approaches and targets against sepsis, effective in both hypo- and hyperinflammatory states. Currently, statins are being evaluated as a viable option in clinical trials. Many agents that have shown favourable results in experimental sepsis are not clinically effective or have not been clinically evaluated. Apart from developing new therapeutic molecules, there is great scope for for developing a variety of drug delivery strategies, such as nanoparticulate carriers and phospholipid-based systems. These nanoparticulate carriers neutralize intracorporeal LPS as well as deliver therapeutic agents to targeted tissues and subcellular locations. Here, we review and critically discuss the present status and new experimental and clinical approaches for therapeutic intervention in sepsis. |Animals[MESH] |Cardiovascular System/metabolism/physiopathology[MESH] |Humans[MESH] |Kidney/immunology/metabolism/physiopathology[MESH] |Lipopolysaccharides/metabolism[MESH] |Liver/immunology/physiopathology[MESH] |Lung/immunology/metabolism/physiopathology[MESH]Therapeutic interventions in sepsis: current and anticipated pharmacol(epmc).pdf DeepDyve Pubget Overpricing