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10.1093/ndt/gfu256 http://scihub22266oqcxt.onion/10.1093/ndt/gfu256 25061123!ä!25061123 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25061123.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nephrol+Dial+Transplant 2014 ; 29 (12): 2286-92 Nephropedia Template TP {{tp|p=25061123|t=2014. A slight increase within the normal range of serum uric acid and the decline in renal function: associations in a community-based population |pdf=|usr=}}{{25061123}} gab.com Text A slight increase within the normal range of serum uric acid and the decline in renal function: associations in a community-based population JO: Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25061123 #FOAvip BACKGROUND: Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. METHODS: We used a nationwide database of 165 847 subjects (aged 29-74, male 40%) who participated in the annual 'Specific Health Check and Guidance in Japan' checkup between 2008 and 2010; we examined the relationship between serum uric acid levels at baseline and 2-year change in the estimated glomerular filtration rate (eGFR) obtained by using the Japanese equation. RESULTS: After adjusting for possible confounders, the eGFR change was inversely correlated with uric acid at baseline. In the multivariable analysis, the decline in eGFR was significantly more rapid in subjects with the slight increase in uric acid (males >/=5.7 mg/dL, females >/=4.4 mg/dL), and the risk for incidental renal insufficiency (eGFR <60 mL/min/1.73 m(2)) was increased at uric acid of >/=6.3 mg/dL in males and >/=5.5 mg/dL in females, compared with the lowest quintile. The multiple linear regression analysis revealed that the effect of uric acid on eGFR changes was significant, especially in females, those with proteinuria and diabetes and those without alcohol consumption. CONCLUSION: This study showed that serum uric acid is independently associated with a more rapid decline of eGFR and incident renal insufficiency, and that a slight increase within the normal range of serum uric acid might be a risk for renal damage in the general population. Twit Text FOAVip A slight increase within the normal range of serum uric acid and the decline in renal function: associations in a community-based population ????Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25061123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25061123 #FOAvip English Wikipedia <ref>{{Cite pmid|25061123}}</ref> A slight increase within the normal range of serum uric acid and the decline in renal function: associations in a community-based population #MMPMID25061123 Kamei K; Konta T; Hirayama A; Suzuki K; Ichikawa K; Fujimoto S; Iseki K; Moriyama T; Yamagata K; Tsuruya K; Kimura K; Narita I; Kondo M; Asahi K; Watanabe T Nephrol Dial Transplant 2014[Dec]; 29 (12): 2286-92 PMID25061123show ga BACKGROUND: Hyperuricemia is a risk factor for adverse renal outcomes in patients with chronic kidney disease. This study investigated the effect of uric acid on renal function in a community-based population. METHODS: We used a nationwide database of 165 847 subjects (aged 29-74, male 40%) who participated in the annual 'Specific Health Check and Guidance in Japan' checkup between 2008 and 2010; we examined the relationship between serum uric acid levels at baseline and 2-year change in the estimated glomerular filtration rate (eGFR) obtained by using the Japanese equation. RESULTS: After adjusting for possible confounders, the eGFR change was inversely correlated with uric acid at baseline. In the multivariable analysis, the decline in eGFR was significantly more rapid in subjects with the slight increase in uric acid (males >/=5.7 mg/dL, females >/=4.4 mg/dL), and the risk for incidental renal insufficiency (eGFR <60 mL/min/1.73 m(2)) was increased at uric acid of >/=6.3 mg/dL in males and >/=5.5 mg/dL in females, compared with the lowest quintile. The multiple linear regression analysis revealed that the effect of uric acid on eGFR changes was significant, especially in females, those with proteinuria and diabetes and those without alcohol consumption. CONCLUSION: This study showed that serum uric acid is independently associated with a more rapid decline of eGFR and incident renal insufficiency, and that a slight increase within the normal range of serum uric acid might be a risk for renal damage in the general population. |*Glomerular Filtration Rate[MESH] |*Population Surveillance[MESH] |Aged[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Humans[MESH] |Hyperuricemia/*blood/epidemiology/physiopathology[MESH] |Japan/epidemiology[MESH] |Male[MESH] |Middle Aged[MESH] |Reference Values[MESH] |Renal Insufficiency, Chronic/blood/epidemiology/*physiopathology[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH]A slight increase within the normal range of serum uric acid and the d(epmc).pdf DeepDyve Pubget Overpricing