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10.1155/2014/260429 http://scihub22266oqcxt.onion/10.1155/2014/260429 25101151!4102082!25101151     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25101151&cmd=llinks): Failed to open stream: HTTP request failed! 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The role of Nrf2-mediated pathway in cardiac remodeling and heart failure |pdf=|usr=}}{{25101151}} gab.com Text The role of Nrf2-mediated pathway in cardiac remodeling and heart failure JO: Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=25101151 #FOAvip Heart failure (HF) is frequently the consequence of sustained, abnormal neurohormonal, and mechanical stress and remains a leading cause of death worldwide. The key pathophysiological process leading to HF is cardiac remodeling, a term referring to maladaptation to cardiac stress at the molecular, cellular, tissue, and organ levels. HF and many of the conditions that predispose one to HF are associated with oxidative stress. Increased generation of reactive oxygen species (ROS) in the heart can directly lead to increased necrosis and apoptosis of cardiomyocytes which subsequently induce cardiac remodeling and dysfunction. Nuclear factor-erythroid-2- (NF-E2-) related factor 2 (Nrf2) is a transcription factor that controls the basal and inducible expression of a battery of antioxidant genes and other cytoprotective phase II detoxifying enzymes that are ubiquitously expressed in the cardiovascular system. Emerging evidence has revealed that Nrf2 and its target genes are critical regulators of cardiovascular homeostasis via the suppression of oxidative stress, which is the key player in the development and progression of HF. The purpose of this review is to summarize evidence that activation of Nrf2 enhances endogenous antioxidant defenses and counteracts oxidative stress-associated cardiac remodeling and HF. Twit Text FOAVip The role of Nrf2-mediated pathway in cardiac remodeling and heart failure ????Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=25101151 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25101151 #FOAvip English Wikipedia <ref>{{Cite pmid|25101151}}</ref> The role of Nrf2-mediated pathway in cardiac remodeling and heart failure #MMPMID25101151 Zhou S; Sun W; Zhang Z; Zheng Y Oxid Med Cell Longev 2014[]; 2014 (ä): 260429 PMID25101151show ga Heart failure (HF) is frequently the consequence of sustained, abnormal neurohormonal, and mechanical stress and remains a leading cause of death worldwide. The key pathophysiological process leading to HF is cardiac remodeling, a term referring to maladaptation to cardiac stress at the molecular, cellular, tissue, and organ levels. HF and many of the conditions that predispose one to HF are associated with oxidative stress. Increased generation of reactive oxygen species (ROS) in the heart can directly lead to increased necrosis and apoptosis of cardiomyocytes which subsequently induce cardiac remodeling and dysfunction. Nuclear factor-erythroid-2- (NF-E2-) related factor 2 (Nrf2) is a transcription factor that controls the basal and inducible expression of a battery of antioxidant genes and other cytoprotective phase II detoxifying enzymes that are ubiquitously expressed in the cardiovascular system. Emerging evidence has revealed that Nrf2 and its target genes are critical regulators of cardiovascular homeostasis via the suppression of oxidative stress, which is the key player in the development and progression of HF. The purpose of this review is to summarize evidence that activation of Nrf2 enhances endogenous antioxidant defenses and counteracts oxidative stress-associated cardiac remodeling and HF. |Animals[MESH] |Diabetes Complications[MESH] |Heart Failure/metabolism/*pathology[MESH] |Humans[MESH] |Hypertension/complications[MESH] |Ischemia/complications[MESH] |Myocardial Infarction/etiology/metabolism/pathology[MESH] |NF-E2-Related Factor 2/antagonists & inhibitors/genetics/*metabolism[MESH] |Oxidative Stress[MESH] |RNA Interference[MESH] |Reactive Oxygen Species/metabolism[MESH]The role of Nrf2-mediated pathway in cardiac remodeling and heart fail(epmc).pdf DeepDyve Pubget Overpricing