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10.1002/stem.1858 http://scihub22266oqcxt.onion/10.1002/stem.1858 25263397!ä!25263397 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25263397&cmd=llinks): Failed to open stream: HTTP request failed! 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Brief reports: TRPM7 Senses mechanical stimulation inducing osteogenesis in human bone marrow mesenchymal stem cells |pdf=|usr=}}{{25263397}} gab.com Text Brief reports: TRPM7 Senses mechanical stimulation inducing osteogenesis in human bone marrow mesenchymal stem cells JO: Stem Cells http://www.kidney.de/pget.php?&tw=1&pmid=25263397 #FOAvip Mesenchymal stem cells (MSCs) are multipotential stem cells residing in the bone marrow. Several studies have shown that mechanical stimulation modulates MSC differentiation through mobilization of second messengers, but the mechanism of mechanotransduction remains poorly understood. In this study, using fluorescence and laser confocal microcopy as well as patch-clamp techniques, we identified the transient receptor potential melastatin type 7 (TRPM7) channel as the key channel involved in mechanotransduction in bone marrow MSCs. TRPM7 knockdown completely abolished the pressure-induced cytosolic Ca(2+) increase and pressure-induced osteogenesis. TRPM7 directly sensed membrane tension, independent of the cytoplasm and the integrity of cytoskeleton. Ca(2+) influx through TRPM7 further triggered Ca(2+) release from the inositol trisphosphate receptor type 2 on the endoplasmic reticulum and promoted NFATc1 nuclear localization and osteogenesis. These results identified a central role of TRPM7 in MSC mechanical stimulation-induced osteogenesis. Twit Text FOAVip Brief reports: TRPM7 Senses mechanical stimulation inducing osteogenesis in human bone marrow mesenchymal stem cells ????Stem Cells http://www.kidney.de/pget.php?&tw=1&pmid=25263397 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25263397 #FOAvip English Wikipedia <ref>{{Cite pmid|25263397}}</ref> Brief reports: TRPM7 Senses mechanical stimulation inducing osteogenesis in human bone marrow mesenchymal stem cells #MMPMID25263397 Xiao E; Yang HQ; Gan YH; Duan DH; He LH; Guo Y; Wang SQ; Zhang Y Stem Cells 2015[Feb]; 33 (2): 615-21 PMID25263397show ga Mesenchymal stem cells (MSCs) are multipotential stem cells residing in the bone marrow. Several studies have shown that mechanical stimulation modulates MSC differentiation through mobilization of second messengers, but the mechanism of mechanotransduction remains poorly understood. In this study, using fluorescence and laser confocal microcopy as well as patch-clamp techniques, we identified the transient receptor potential melastatin type 7 (TRPM7) channel as the key channel involved in mechanotransduction in bone marrow MSCs. TRPM7 knockdown completely abolished the pressure-induced cytosolic Ca(2+) increase and pressure-induced osteogenesis. TRPM7 directly sensed membrane tension, independent of the cytoplasm and the integrity of cytoskeleton. Ca(2+) influx through TRPM7 further triggered Ca(2+) release from the inositol trisphosphate receptor type 2 on the endoplasmic reticulum and promoted NFATc1 nuclear localization and osteogenesis. These results identified a central role of TRPM7 in MSC mechanical stimulation-induced osteogenesis. |*Osteogenesis[MESH] |*Pressure[MESH] |Bone Marrow Cells/cytology/*metabolism[MESH] |Cells, Cultured[MESH] |Humans[MESH] |Mechanotransduction, Cellular/*physiology[MESH] |Mesenchymal Stem Cells/cytology/*metabolism[MESH] |Protein Serine-Threonine Kinases/*metabolism[MESH]Brief reports: TRPM7 Senses mechanical stimulation inducing osteogenes(epmc).pdf DeepDyve Pubget Overpricing