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10.1089/jir.2014.0038 http://scihub22266oqcxt.onion/10.1089/jir.2014.0038 25321315!4350140!25321315     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25321315&cmd=llinks): Failed to open stream: HTTP request failed! 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Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery |pdf=|usr=}}{{25321315}} gab.com Text Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery JO: J Interferon Cytokine Res http://www.kidney.de/pget.php?&tw=1&pmid=25321315 #FOAvip Hydroxychloroquine (HCQ) is an antimalarial drug also used in treating autoimmune diseases. Its antiviral activity was demonstrated in restricting HIV infection in vitro; however, the clinical implications remain controversial. Infection with dengue virus (DENV) is a global public health problem, and we lack an antiviral drug for DENV. Here, we evaluated the anti-DENV potential of treatment with HCQ. Immunofluorescence assays demonstrated that HCQ could inhibit DENV serotype 1-4 infection in vitro. RT-qPCR analysis of HCQ-treated cells showed induced expression of interferon (IFN)-related antiviral proteins and certain inflammatory cytokines. Mechanistic study suggested that HCQ activated the innate immune signaling pathways of IFN-beta, AP-1, and NFkappaB. Knocking down mitochondrial antiviral signaling protein (MAVS), inhibiting TANK binding kinase 1 (TBK1)/inhibitor-kappaB kinase varepsilon (IKKvarepsilon), and blocking type I IFN receptor reduced the efficiency of HCQ against DENV-2 infection. Furthermore, HCQ significantly induced cellular production of reactive oxygen species (ROS), which was involved in the host defense system. Suppression of ROS production attenuated the innate immune activation and anti-DENV-2 effect of HCQ. In summary, HCQ triggers the host defense machinery by inducing ROS- and MAVS-mediated innate immune activation against DENV infection and may be a candidate drug for DENV infection. Twit Text FOAVip Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery ????J Interferon Cytokine Res http://www.kidney.de/pget.php?&tw=1&pmid=25321315 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25321315 #FOAvip English Wikipedia <ref>{{Cite pmid|25321315}}</ref> Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery #MMPMID25321315 Wang LF; Lin YS; Huang NC; Yu CY; Tsai WL; Chen JJ; Kubota T; Matsuoka M; Chen SR; Yang CS; Lu RW; Lin YL; Chang TH J Interferon Cytokine Res 2015[Mar]; 35 (3): 143-56 PMID25321315show ga Hydroxychloroquine (HCQ) is an antimalarial drug also used in treating autoimmune diseases. Its antiviral activity was demonstrated in restricting HIV infection in vitro; however, the clinical implications remain controversial. Infection with dengue virus (DENV) is a global public health problem, and we lack an antiviral drug for DENV. Here, we evaluated the anti-DENV potential of treatment with HCQ. Immunofluorescence assays demonstrated that HCQ could inhibit DENV serotype 1-4 infection in vitro. RT-qPCR analysis of HCQ-treated cells showed induced expression of interferon (IFN)-related antiviral proteins and certain inflammatory cytokines. Mechanistic study suggested that HCQ activated the innate immune signaling pathways of IFN-beta, AP-1, and NFkappaB. Knocking down mitochondrial antiviral signaling protein (MAVS), inhibiting TANK binding kinase 1 (TBK1)/inhibitor-kappaB kinase varepsilon (IKKvarepsilon), and blocking type I IFN receptor reduced the efficiency of HCQ against DENV-2 infection. Furthermore, HCQ significantly induced cellular production of reactive oxygen species (ROS), which was involved in the host defense system. Suppression of ROS production attenuated the innate immune activation and anti-DENV-2 effect of HCQ. In summary, HCQ triggers the host defense machinery by inducing ROS- and MAVS-mediated innate immune activation against DENV infection and may be a candidate drug for DENV infection. |Adaptor Proteins, Signal Transducing/metabolism[MESH] |Animals[MESH] |Cell Line[MESH] |Dengue Virus/*immunology[MESH] |Dengue/*drug therapy[MESH] |Epithelial Cells/*drug effects/immunology/virology[MESH] |Gene Expression Regulation, Viral/drug effects[MESH] |Humans[MESH] |Hydroxychloroquine/*pharmacology[MESH] |Immunity, Innate/drug effects[MESH] |Interferons/genetics/*metabolism[MESH] |Mice[MESH] |NF-kappa B/metabolism[MESH] |Reactive Oxygen Species/metabolism[MESH]Hydroxychloroquine-inhibited dengue virus is associated with host defe(epmc).pdf DeepDyve Pubget Overpricing