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suck abstract from ncbi


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pmid2547951      J+Hum+Hypertens 1989 ; 3 (2): 137-40
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  • An association between mineral metabolism and the renin-aldosterone system in human hypertension #MMPMID2547951
  • Lind L; Wide L; Sorensen OH; Ljunghall S
  • J Hum Hypertens 1989[Apr]; 3 (2): 137-40 PMID2547951show ga
  • In recent years abnormalities of calcium metabolism have been described in human hypertension. In this study, the relationships between indices of calcium metabolism and the renin-aldosterone system were studied in 39 subjects with untreated essential hypertension. No significant associations were found between the major determinants of calcium metabolism (plasma ionised calcium, parathyroid hormone and 1,25(OH)2-vitamin D) and the renin-aldosterone system. Serum magnesium was, however, positively correlated to plasma renin activity (PRA) (r = 0.38, P less than 0.05) while both 24 h urinary excretion of calcium and cAMP were found to be correlated to both PRA and urinary aldosterone in a positive way (r = 0.39-0.42, P less than 0.01 and r = 0.33-0.57, P less than 0.01, respectively). In this study there was no other evidence of any major influence of the renin-aldosterone status on the calcium balance in human hypertension. The urinary leak of calcium might be determined by the action of the renin-aldosterone system.
  • |Adult[MESH]
  • |Aldosterone/*metabolism[MESH]
  • |Calcium/urine[MESH]
  • |Cyclic AMP/urine[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hypertension/blood/*metabolism/urine[MESH]
  • |Magnesium/blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Minerals/*metabolism[MESH]
  • |Renin/blood/*metabolism[MESH]


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