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10.1016/j.ccell.2014.10.006 http://scihub22266oqcxt.onion/10.1016/j.ccell.2014.10.006 25517747!4269830!25517747     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25517747&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25517747.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Cell 2014 ; 26 (5): 605-22 Nephropedia Template TP {{tp|p=25517747|t=2014. Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia |pdf=|usr=}}{{25517747}} gab.com Text Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25517747 #FOAvip Ten antiangiogenic drugs targeting VEGF or its receptors are approved for cancer treatment. However, these agents, intended to block tumors' blood supply, may cause hypoxia, which may fuel tumor progression and treatment resistance. Emerging clinical data suggest that patients whose tumor perfusion or oxygenation increases in response to these agents may actually survive longer. Hence, strategies aimed at alleviating tumor hypoxia while improving perfusion may enhance the outcome of radiotherapy, chemotherapy, and immunotherapy. Here I summarize lessons learned from preclinical and clinical studies over the past decade and propose strategies for improving antiangiogenic therapy outcomes for malignant and nonmalignant diseases. Twit Text FOAVip Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25517747 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25517747 #FOAvip English Wikipedia <ref>{{Cite pmid|25517747}}</ref> Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia #MMPMID25517747 Jain RK Cancer Cell 2014[Nov]; 26 (5): 605-22 PMID25517747show ga Ten antiangiogenic drugs targeting VEGF or its receptors are approved for cancer treatment. However, these agents, intended to block tumors' blood supply, may cause hypoxia, which may fuel tumor progression and treatment resistance. Emerging clinical data suggest that patients whose tumor perfusion or oxygenation increases in response to these agents may actually survive longer. Hence, strategies aimed at alleviating tumor hypoxia while improving perfusion may enhance the outcome of radiotherapy, chemotherapy, and immunotherapy. Here I summarize lessons learned from preclinical and clinical studies over the past decade and propose strategies for improving antiangiogenic therapy outcomes for malignant and nonmalignant diseases. |Angiogenesis Inhibitors/pharmacology/*therapeutic use[MESH] |Animals[MESH] |Cell Hypoxia[MESH] |Drug Resistance, Neoplasm[MESH] |Drug Synergism[MESH] |Humans[MESH] |Immunotherapy[MESH] |Neoplasms/blood supply/*drug therapy[MESH]Antiangiogenesis strategies revisited: from starving tumors to allevia(epmc).pdf DeepDyve Pubget Overpricing