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10.1002/cphy.c140002 http://scihub22266oqcxt.onion/10.1002/cphy.c140002 25589264!5810970!25589264     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25589264.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Compr+Physiol 2015 ; 5 (1): 45-98 Nephropedia Template TP {{tp|p=25589264|t=2015. Distal convoluted tubule |pdf=|usr=}}{{25589264}} gab.com Text Distal convoluted tubule JO: Compr Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25589264 #FOAvip The distal convoluted tubule (DCT) is a short nephron segment, interposed between the macula densa and collecting duct. Even though it is short, it plays a key role in regulating extracellular fluid volume and electrolyte homeostasis. DCT cells are rich in mitochondria, and possess the highest density of Na+/K+-ATPase along the nephron, where it is expressed on the highly amplified basolateral membranes. DCT cells are largely water impermeable, and reabsorb sodium and chloride across the apical membrane via electroneurtral pathways. Prominent among this is the thiazide-sensitive sodium chloride cotransporter, target of widely used diuretic drugs. These cells also play a key role in magnesium reabsorption, which occurs predominantly, via a transient receptor potential channel (TRPM6). Human genetic diseases in which DCT function is perturbed have provided critical insights into the physiological role of the DCT, and how transport is regulated. These include Familial Hyperkalemic Hypertension, the salt-wasting diseases Gitelman syndrome and EAST syndrome, and hereditary hypomagnesemias. The DCT is also established as an important target for the hormones angiotensin II and aldosterone; it also appears to respond to sympathetic-nerve stimulation and changes in plasma potassium. Here, we discuss what is currently known about DCT physiology. Early studies that determined transport rates of ions by the DCT are described, as are the channels and transporters expressed along the DCT with the advent of molecular cloning. Regulation of expression and activity of these channels and transporters is also described; particular emphasis is placed on the contribution of genetic forms of DCT dysregulation to our understanding. Twit Text FOAVip Distal convoluted tubule ????Compr Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25589264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25589264 #FOAvip English Wikipedia <ref>{{Cite pmid|25589264}}</ref> Distal convoluted tubule #MMPMID25589264 McCormick JA; Ellison DH Compr Physiol 2015[Jan]; 5 (1): 45-98 PMID25589264show ga The distal convoluted tubule (DCT) is a short nephron segment, interposed between the macula densa and collecting duct. Even though it is short, it plays a key role in regulating extracellular fluid volume and electrolyte homeostasis. DCT cells are rich in mitochondria, and possess the highest density of Na+/K+-ATPase along the nephron, where it is expressed on the highly amplified basolateral membranes. DCT cells are largely water impermeable, and reabsorb sodium and chloride across the apical membrane via electroneurtral pathways. Prominent among this is the thiazide-sensitive sodium chloride cotransporter, target of widely used diuretic drugs. These cells also play a key role in magnesium reabsorption, which occurs predominantly, via a transient receptor potential channel (TRPM6). Human genetic diseases in which DCT function is perturbed have provided critical insights into the physiological role of the DCT, and how transport is regulated. These include Familial Hyperkalemic Hypertension, the salt-wasting diseases Gitelman syndrome and EAST syndrome, and hereditary hypomagnesemias. The DCT is also established as an important target for the hormones angiotensin II and aldosterone; it also appears to respond to sympathetic-nerve stimulation and changes in plasma potassium. Here, we discuss what is currently known about DCT physiology. Early studies that determined transport rates of ions by the DCT are described, as are the channels and transporters expressed along the DCT with the advent of molecular cloning. Regulation of expression and activity of these channels and transporters is also described; particular emphasis is placed on the contribution of genetic forms of DCT dysregulation to our understanding. |Animals[MESH] |Biological Transport/physiology[MESH] |Electrophysiological Phenomena/physiology[MESH] |Humans[MESH] |Kidney Tubules, Distal/anatomy & histology/metabolism/*physiology[MESH] |Magnesium/metabolism[MESH] |Potassium/metabolism[MESH] |Renal Tubular Transport, Inborn Errors/genetics/metabolism/physiopathology[MESH]Distal convoluted tubule (epmc).pdf DeepDyve Pubget Overpricing