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10.1016/j.alcohol.2015.02.002 http://scihub22266oqcxt.onion/10.1016/j.alcohol.2015.02.002 25800156!4414871!25800156     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25800156.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Alcohol 2015 ; 49 (3): 265-73 Nephropedia Template TP {{tp|p=25800156|t=2015. Effect of acute and prolonged alcohol administration on Mg(2+) homeostasis in cardiac cells |pdf=|usr=}}{{25800156}} gab.com Text Effect of acute and prolonged alcohol administration on Mg(2+) homeostasis in cardiac cells JO: Alcohol http://www.kidney.de/pget.php?&tw=1&pmid=25800156 #FOAvip Alcoholic cardiomyopathy represents a major clinical complication in chronic alcoholics. Previous studies from our laboratory indicate that acute and chronic exposure of liver cells to ethanol results in a major loss of cellular Mg(2+) as a result of alcohol oxidation. We investigated whether exposure to ethanol induces a similar Mg(2+) loss in cardiac cells. The results indicate that chronic exposure to a 6% ethanol-containing diet depleted cardiac myocytes of >25% of their cellular Mg(2+) content. Acute ethanol exposure, instead, induced a time- and dose-dependent manner of Mg(2+) extrusion from perfused hearts and collagenase-dispersed cardiac ventricular myocytes. Pretreatment with chlormethiazole prevented ethanol-induced Mg(2+) loss to a large extent, suggesting a role of ethanol oxidation via cyP4502E1 in the process. Magnesium extrusion across the sarcolemma occurred via the amiloride-inhibited Na(+)/Mg(2+) exchanger. Taken together, our data indicate that Mg(2+) extrusion also occurs in cardiac cells exposed to ethanol as a result of alcohol metabolism by cyP4502E1. The extrusion, which is mediated by the Na(+)/Mg(2+) exchanger, only occurs at doses of ethanol >/=0.1%, and depends on ethanol-induced decline in cellular ATP. The significance of Mg(2+) extrusion for the onset of alcoholic cardiomyopathy remains to be elucidated. Twit Text FOAVip Effect of acute and prolonged alcohol administration on Mg(2+) homeostasis in cardiac cells ????Alcohol http://www.kidney.de/pget.php?&tw=1&pmid=25800156 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25800156 #FOAvip English Wikipedia <ref>{{Cite pmid|25800156}}</ref> Effect of acute and prolonged alcohol administration on Mg(2+) homeostasis in cardiac cells #MMPMID25800156 Romani AM Alcohol 2015[May]; 49 (3): 265-73 PMID25800156show ga Alcoholic cardiomyopathy represents a major clinical complication in chronic alcoholics. Previous studies from our laboratory indicate that acute and chronic exposure of liver cells to ethanol results in a major loss of cellular Mg(2+) as a result of alcohol oxidation. We investigated whether exposure to ethanol induces a similar Mg(2+) loss in cardiac cells. The results indicate that chronic exposure to a 6% ethanol-containing diet depleted cardiac myocytes of >25% of their cellular Mg(2+) content. Acute ethanol exposure, instead, induced a time- and dose-dependent manner of Mg(2+) extrusion from perfused hearts and collagenase-dispersed cardiac ventricular myocytes. Pretreatment with chlormethiazole prevented ethanol-induced Mg(2+) loss to a large extent, suggesting a role of ethanol oxidation via cyP4502E1 in the process. Magnesium extrusion across the sarcolemma occurred via the amiloride-inhibited Na(+)/Mg(2+) exchanger. Taken together, our data indicate that Mg(2+) extrusion also occurs in cardiac cells exposed to ethanol as a result of alcohol metabolism by cyP4502E1. The extrusion, which is mediated by the Na(+)/Mg(2+) exchanger, only occurs at doses of ethanol >/=0.1%, and depends on ethanol-induced decline in cellular ATP. The significance of Mg(2+) extrusion for the onset of alcoholic cardiomyopathy remains to be elucidated. |Acid Sensing Ion Channel Blockers/pharmacology[MESH] |Adenosine Triphosphate/metabolism[MESH] |Amiloride/pharmacology[MESH] |Animals[MESH] |Central Nervous System Depressants/administration & dosage/*pharmacology[MESH] |Cytochrome P-450 CYP2E1 Inhibitors/pharmacology[MESH] |Cytochrome P-450 CYP2E1/metabolism[MESH] |Ethanol/administration & dosage/*pharmacology[MESH] |Heart Ventricles/cytology[MESH] |Homeostasis/drug effects[MESH] |Ion Exchange[MESH] |Magnesium/*metabolism[MESH] |Male[MESH] |Myocytes, Cardiac/*drug effects/metabolism[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Sarcolemma/*drug effects/metabolism[MESH]Effect of acute and prolonged alcohol administration on Mg(2+) homeost(epmc).pdf DeepDyve Pubget Overpricing