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10.1016/j.cell.2015.01.036 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.01.036 25815993!4525717!25815993     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25815993.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2015 ; 161 (1): 161-172 Nephropedia Template TP {{tp|p=25815993|t=2015. A century of cholesterol and coronaries: from plaques to genes to statins |pdf=|usr=}}{{25815993}} gab.com Text A century of cholesterol and coronaries: from plaques to genes to statins JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25815993 #FOAvip One-fourth of all deaths in industrialized countries result from coronary heart disease. A century of research has revealed the essential causative agent: cholesterol-carrying low-density lipoprotein (LDL). LDL is controlled by specific receptors (LDLRs) in liver that remove it from blood. Mutations that eliminate LDLRs raise LDL and cause heart attacks in childhood, whereas mutations that raise LDLRs reduce LDL and diminish heart attacks. If we are to eliminate coronary disease, lowering LDL should be the primary goal. Effective means to achieve this goal are currently available. The key questions are: who to treat, when to treat, and how long to treat. Twit Text FOAVip A century of cholesterol and coronaries: from plaques to genes to statins ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25815993 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25815993 #FOAvip English Wikipedia <ref>{{Cite pmid|25815993}}</ref> A century of cholesterol and coronaries: from plaques to genes to statins #MMPMID25815993 Goldstein JL; Brown MS Cell 2015[Mar]; 161 (1): 161-172 PMID25815993show ga One-fourth of all deaths in industrialized countries result from coronary heart disease. A century of research has revealed the essential causative agent: cholesterol-carrying low-density lipoprotein (LDL). LDL is controlled by specific receptors (LDLRs) in liver that remove it from blood. Mutations that eliminate LDLRs raise LDL and cause heart attacks in childhood, whereas mutations that raise LDLRs reduce LDL and diminish heart attacks. If we are to eliminate coronary disease, lowering LDL should be the primary goal. Effective means to achieve this goal are currently available. The key questions are: who to treat, when to treat, and how long to treat. |Animals[MESH] |Cardiovascular Diseases/drug therapy/genetics/pathology[MESH] |Cholesterol/*metabolism[MESH] |Coronary Vessels/metabolism/*pathology[MESH] |Dietary Fats/metabolism[MESH] |Humans[MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use[MESH] |Plaque, Atherosclerotic/*drug therapy/genetics/metabolism[MESH]A century of cholesterol and coronaries: from plaques to genes to stat(epmc).pdf DeepDyve Pubget Overpricing