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10.1016/j.preghy.2013.04.061 http://scihub22266oqcxt.onion/10.1016/j.preghy.2013.04.061 26105891!�!26105891 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26105891&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26105891.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Pregnancy+Hypertens 2013 ; 3 (2): 79 Nephropedia Template TP {{tp|p=26105891|t=2013. PP034 Renal histology in preeclampsia: A special role for the podocyte |pdf=|usr=}}{{26105891}} gab.com Text PP034 Renal histology in preeclampsia: A special role for the podocyte JO: Pregnancy Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=26105891 #FOAvip INTRODUCTION: In preeclampsia (PE), the kidney is one of the major target organs. Growing evidence suggests PE increases the risk of subsequent microalbuminuria and end-stage renal disease (ESRD). Endotheliosis and podocyte changes due to anti-angiogenic factors seem to be salient features of PE. However, it is unknown whether chronic lesions are present in PE patients that could contribute to this increased risk. OBJECTIVES: We hypothesized that women with PE and young women with chronic hypertension might show similarity in renal lesions. Furthermore, we investigated if the number of podocytes within the kidney is decreased under these different circumstances. Methods We performed a search for renal autopsy-tissues using a nationwide computerized database (PALGA) to collect a unique large cohort of preeclamptic patients (n=11). Three control groups were included consisting of young women who died during pregnancy without hypertension (n=25) and non-pregnant controls with (n=14) and without (n=13) chronic hypertension. WT-1 staining was used to quantify the number of podocytes. Results Women with PE had MPGN-like lesions without immune-deposits. Tram tracking and podocyte changes were exclusively observed in these patients. Endotheliosis was significantly more present in PE, but sporadically seen in pregnant- and hypertensive controls. Chronic ischaemic lesions were predominantly found in young women with chronic hypertension, and not in PE and other controls. No differences were found in glomerular podocyte number between the study groups. CONCLUSION: All women with PE had MPGN-like lesions in their kidneys which was therefore regarded characteristic for PE. In contrast, no chronic lesions were observed in PE which could explain the increased risk of impaired renal function later in life. Interestingly, we demonstrated no difference in podocyte number between study groups. These results might suggest that neither persistent hypertension or dysbalance in angiogenic factors (i.e. preeclampsia) cause an observable change in podocyte number within the kidney. Twit Text FOAVip PP034 Renal histology in preeclampsia: A special role for the podocyte ????Pregnancy Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=26105891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26105891 #FOAvip English Wikipedia <ref>{{Cite pmid|26105891}}</ref> PP034 Renal histology in preeclampsia: A special role for the podocyte #MMPMID26105891 Penning M; Bloemenkamp K; Schutte J; Bruijn JA; Bajema I; Baelde H Pregnancy Hypertens 2013[Apr]; 3 (2): 79 PMID26105891show ga INTRODUCTION: In preeclampsia (PE), the kidney is one of the major target organs. Growing evidence suggests PE increases the risk of subsequent microalbuminuria and end-stage renal disease (ESRD). Endotheliosis and podocyte changes due to anti-angiogenic factors seem to be salient features of PE. However, it is unknown whether chronic lesions are present in PE patients that could contribute to this increased risk. OBJECTIVES: We hypothesized that women with PE and young women with chronic hypertension might show similarity in renal lesions. Furthermore, we investigated if the number of podocytes within the kidney is decreased under these different circumstances. Methods We performed a search for renal autopsy-tissues using a nationwide computerized database (PALGA) to collect a unique large cohort of preeclamptic patients (n=11). Three control groups were included consisting of young women who died during pregnancy without hypertension (n=25) and non-pregnant controls with (n=14) and without (n=13) chronic hypertension. WT-1 staining was used to quantify the number of podocytes. Results Women with PE had MPGN-like lesions without immune-deposits. Tram tracking and podocyte changes were exclusively observed in these patients. Endotheliosis was significantly more present in PE, but sporadically seen in pregnant- and hypertensive controls. Chronic ischaemic lesions were predominantly found in young women with chronic hypertension, and not in PE and other controls. No differences were found in glomerular podocyte number between the study groups. CONCLUSION: All women with PE had MPGN-like lesions in their kidneys which was therefore regarded characteristic for PE. In contrast, no chronic lesions were observed in PE which could explain the increased risk of impaired renal function later in life. Interestingly, we demonstrated no difference in podocyte number between study groups. These results might suggest that neither persistent hypertension or dysbalance in angiogenic factors (i.e. preeclampsia) cause an observable change in podocyte number within the kidney. �PP034 Renal histology in preeclampsia: A special role for the podocyt(epmc).pdf DeepDyve Pubget Overpricing