
| 10.1093/ndt/gfv228
http://scihub22266oqcxt.onion/10.1093/ndt/gfv228
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Nephrol+Dial+Transplant 2015 ; 30 (11): 1862-9 Nephropedia Template TP
gab.com Text
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Spontaneous remission of proteinuria is a frequent event in phospholipase A2 receptor antibody-negative patients with membranous nephropathy #MMPMID26142398Hoxha E; Harendza S; Pinnschmidt HO; Tomas NM; Helmchen U; Panzer U; Stahl RANephrol Dial Transplant 2015[Nov]; 30 (11): 1862-9 PMID26142398show ga
BACKGROUND: Phospholipase A2 receptor antibodies (PLA2R-Ab) and thrombospondin type-1 domain-containing 7A antibodies (THSD7A-Ab) are present in 70-80% of patients with membranous nephropathy (MN). Little, however, is known about the pathogenesis of MN and the clinical outcome in PLA2R-Ab- and THSD7A-Ab-negative patients. METHODS: In this prospective multicentre observational study, the clinical outcome of 37 patients with biopsy-proven MN who were negative for PLA2R-Ab and THSD7A-Ab in the serum was analysed. RESULTS: A total of 198 patients were screened for inclusion in the study. Of these, 157 patients were positive for PLA2R-Ab and 4 patients for THSD7A-Ab. The remaining 37 patients were negative for both antibodies were and included in this study. Six patients died during the follow-up, five because of malignant diseases and one of an infection. One patient went into end-stage renal disease, and two patients were lost to follow-up. The remaining 28 patients were followed for at least 24 months (35.6 +/- 8.9 months). Seventeen patients received immunosuppressive (IS) therapy, and 11 received supportive care only. At the end of the follow-up, 14 of the 17 patients treated with immunosuppressants and 10 of 11 patients on supportive therapy had a remission of proteinuria. The time to reach remission of proteinuria and serum creatinine levels at the end of the follow-up were not different between both groups. A univariate Cox regression analysis indicated that the use of immunosuppression did not alter the chance to reach a remission of proteinuria. CONCLUSIONS: A high number of PLA2R-Ab- and THSD7A-Ab-negative patients with MN have a good prognosis and might not need IS therapy.|Adult[MESH]|Aged[MESH]|Autoantibodies/*blood[MESH]|Female[MESH]|Glomerulonephritis, Membranous/*physiopathology[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Prospective Studies[MESH]|Proteinuria/etiology/*physiopathology[MESH]|Receptors, Phospholipase A2/*immunology[MESH]|Remission, Spontaneous[MESH]|Thrombospondins/*immunology[MESH]|Treatment Outcome[MESH]
  
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