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10.3389/fphar.2015.00203

http://scihub22266oqcxt.onion/10.3389/fphar.2015.00203
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suck abstract from ncbi


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pmid26483685      Front+Pharmacol 2015 ; 6 (�): 203
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  • Cardiac cAMP: production, hydrolysis, modulation and detection #MMPMID26483685
  • Boularan C; Gales C
  • Front Pharmacol 2015[]; 6 (�): 203 PMID26483685show ga
  • Cyclic adenosine 3',5'-monophosphate (cAMP) modulates a broad range of biological processes including the regulation of cardiac myocyte contractile function where it constitutes the main second messenger for beta-adrenergic receptors' signaling to fulfill positive chronotropic, inotropic and lusitropic effects. A growing number of studies pinpoint the role of spatial organization of the cAMP signaling as an essential mechanism to regulate cAMP outcomes in cardiac physiology. Here, we will briefly discuss the complexity of cAMP synthesis and degradation in the cardiac context, describe the way to detect it and review the main pharmacological arsenal to modulate its availability.



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