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10.1080/21505594.2015.1122165 http://scihub22266oqcxt.onion/10.1080/21505594.2015.1122165 26632342!4994834!26632342     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26632342.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Virulence 2016 ; 7 (2): 110-8 Nephropedia Template TP {{tp|p=26632342|t=2016. Human parvovirus B19 VP1u Protein as inflammatory mediators induces liver injury in naive mice |pdf=|usr=}}{{26632342}} gab.com Text Human parvovirus B19 VP1u Protein as inflammatory mediators induces liver injury in naive mice JO: Virulence http://www.kidney.de/pget.php?&tw=1&pmid=26632342 #FOAvip Human parvovirus B19 (B19V) is a human pathogen known to be associated with many non-erythroid diseases, including hepatitis. Although B19V VP1-unique region (B19-VP1u) has crucial roles in the pathogenesis of B19V infection, the influence of B19-VP1u proteins on hepatic injury is still obscure. This study investigated the effect and possible inflammatory signaling of B19-VP1u in livers from BALB/c mice that were subcutaneously inoculated with VP1u-expressing COS-7 cells. The in vivo effects of B19-VP1u were analyzed by using live animal imaging system (IVIS), Haematoxylin-Eosin staining, gel zymography, and immunoblotting after inoculation. Markedly hepatocyte disarray and lymphocyte infiltration, enhanced matrix metalloproteinase (MMP)-9 activity and increased phosphorylation of p38, ERK, IKK-alpha, IkappaB and NF-kappaB (p-p65) proteins were observed in livers from BALB/c mice receiving COS-7 cells expressing B19-VP1u as well as the significantly increased CRP, IL-1beta and IL-6. Notably, IFN-gamma and phosphorylated STAT1, but not STAT3, were also significantly increased in the livers of BALB/c mice that were subcutaneously inoculated with VP1u-expressing COS-7 cells. These findings revealed the effects of B19-VP1u on liver injury and suggested that B19-VP1u may have a role as mediators of inflammation in B19V infection. Twit Text FOAVip Human parvovirus B19 VP1u Protein as inflammatory mediators induces liver injury in naive mice ????Virulence http://www.kidney.de/pget.php?&tw=1&pmid=26632342 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26632342 #FOAvip English Wikipedia <ref>{{Cite pmid|26632342}}</ref> Human parvovirus B19 VP1u Protein as inflammatory mediators induces liver injury in naive mice #MMPMID26632342 Hsu TC; Chiu CC; Chang SC; Chan HC; Shi YF; Chen TY; Tzang BS Virulence 2016[]; 7 (2): 110-8 PMID26632342show ga Human parvovirus B19 (B19V) is a human pathogen known to be associated with many non-erythroid diseases, including hepatitis. Although B19V VP1-unique region (B19-VP1u) has crucial roles in the pathogenesis of B19V infection, the influence of B19-VP1u proteins on hepatic injury is still obscure. This study investigated the effect and possible inflammatory signaling of B19-VP1u in livers from BALB/c mice that were subcutaneously inoculated with VP1u-expressing COS-7 cells. The in vivo effects of B19-VP1u were analyzed by using live animal imaging system (IVIS), Haematoxylin-Eosin staining, gel zymography, and immunoblotting after inoculation. Markedly hepatocyte disarray and lymphocyte infiltration, enhanced matrix metalloproteinase (MMP)-9 activity and increased phosphorylation of p38, ERK, IKK-alpha, IkappaB and NF-kappaB (p-p65) proteins were observed in livers from BALB/c mice receiving COS-7 cells expressing B19-VP1u as well as the significantly increased CRP, IL-1beta and IL-6. Notably, IFN-gamma and phosphorylated STAT1, but not STAT3, were also significantly increased in the livers of BALB/c mice that were subcutaneously inoculated with VP1u-expressing COS-7 cells. These findings revealed the effects of B19-VP1u on liver injury and suggested that B19-VP1u may have a role as mediators of inflammation in B19V infection. |Animals[MESH] |COS Cells[MESH] |Capsid Proteins/genetics/immunology/*metabolism[MESH] |Chlorocebus aethiops[MESH] |Hepatitis, Viral, Animal/immunology/*pathology/*virology[MESH] |Inflammation Mediators/*metabolism[MESH] |Interleukin-1beta/genetics/metabolism[MESH] |Interleukin-6/genetics/metabolism[MESH] |Intravital Microscopy[MESH] |Liver/immunology/metabolism/*pathology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Parvovirus B19, Human/*metabolism/*pathogenicity[MESH] |Phosphorylation[MESH]Human parvovirus B19 VP1u Protein as inflammatory mediators induces li(epmc).pdf DeepDyve Pubget Overpricing