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10.1186/s12936-016-1163-3 http://scihub22266oqcxt.onion/10.1186/s12936-016-1163-3 26888537!4758146!26888537     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26888537&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26888537.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Malar+J 2016 ; 15 (ä): 95 Nephropedia Template TP {{tp|p=26888537|t=2016. Transmission-blocking strategies: the roadmap from laboratory bench to the community |pdf=|usr=}}{{26888537}} gab.com Text Transmission-blocking strategies: the roadmap from laboratory bench to the community JO: Malar J http://www.kidney.de/pget.php?&tw=1&pmid=26888537 #FOAvip Malaria remains one of the most prevalent tropical and infectious diseases in the world, with an estimated more than 200 million clinical cases every year. In recent years, the mosquito stages of the parasite life cycle have received renewed attention with some progress being made in the development of transmission-blocking strategies. From gametocytes to late ookinetes, some attractive antigenic targets have been found and tested in order to develop a transmission blocking vaccine, and drugs are being currently screened for gametocytocidal activity, and also some new and less conventional approaches are drawing increased attention, such as genetically modified and fungus-infected mosquitoes that become refractory to Plasmodium infection. In this review some of those strategies focusing on the progress made so far will be summarized, but also, the challenges that come from the translation of early promising benchwork resulting in successful applications in the field. To do this, the available literature will be screened and all the pieces of the puzzle must be combined: from molecular biology to epidemiologic and clinical data. Twit Text FOAVip Transmission-blocking strategies: the roadmap from laboratory bench to the community ????Malar J http://www.kidney.de/pget.php?&tw=1&pmid=26888537 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26888537 #FOAvip English Wikipedia <ref>{{Cite pmid|26888537}}</ref> Transmission-blocking strategies: the roadmap from laboratory bench to the community #MMPMID26888537 Goncalves D; Hunziker P Malar J 2016[Feb]; 15 (ä): 95 PMID26888537show ga Malaria remains one of the most prevalent tropical and infectious diseases in the world, with an estimated more than 200 million clinical cases every year. In recent years, the mosquito stages of the parasite life cycle have received renewed attention with some progress being made in the development of transmission-blocking strategies. From gametocytes to late ookinetes, some attractive antigenic targets have been found and tested in order to develop a transmission blocking vaccine, and drugs are being currently screened for gametocytocidal activity, and also some new and less conventional approaches are drawing increased attention, such as genetically modified and fungus-infected mosquitoes that become refractory to Plasmodium infection. In this review some of those strategies focusing on the progress made so far will be summarized, but also, the challenges that come from the translation of early promising benchwork resulting in successful applications in the field. To do this, the available literature will be screened and all the pieces of the puzzle must be combined: from molecular biology to epidemiologic and clinical data. |Animals[MESH] |Antimalarials/pharmacology/therapeutic use[MESH] |Culicidae[MESH] |Insect Vectors[MESH] |Malaria/drug therapy/*prevention & control/transmission[MESH]Transmission-blocking strategies: the roadmap from laboratory bench to(epmc).pdf DeepDyve Pubget Overpricing