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10.1016/j.jep.2016.03.057 http://scihub22266oqcxt.onion/10.1016/j.jep.2016.03.057 27036629!ä!27036629 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27036629&cmd=llinks): Failed to open stream: HTTP request failed! 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Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-kappaB signaling pathway and MMP-9 expression |pdf=|usr=}}{{27036629}} gab.com Text Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-kappaB signaling pathway and MMP-9 expression JO: J Ethnopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27036629 #FOAvip ETHNOPHARMACOLOGICAL RELEVANCE: Kegan Liyan oral liquid (KGLY), a Chinese prescription modified from classic formulas Yin-Qiao-San (from TCM classic Wenbing Tiaobian) and Shen-Jie-San (first mentioned in Shanghan Wenyi Tiaobian), has been reported to exert heat-clearing and detoxifying effects and used extensively for the treatment of severe pulmonary diseases in clinics including influenza, cough and pneumonia. AIM OF THIS STUDY: The purpose of this study was to investigate the protective effect of KGLY on lipopolysaccharide (LPS) induced acute lung injury (ALI) in mice and to illuminate the underlying mechanisms. MATERIALS AND METHODS: Mice were orally administrated with KGLY (50, 100 and 150mg/kg) before intratracheal instillation of LPS. 24h post LPS challenge, lung tissues and the bronchoalveolar lavage fluid (BALF) were collected for lung wet/dry (W/D) weight ratio, histopathological examinations and biochemical analyses. The cell counts, protein concentration, interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein-2 (MIP-2) in BALF, superoxide dismutase (SOD), glutathione (GSH), myeloperoxidase (MPO) and malondialdehyde (MDA) levels were detected. Meanwhile, the activation of toll-like receptor 4 (TLR4), nuclear factor kappa B (NF-kappaB), as well as matrix metalloproteinases 9 (MMP-9) were determined by western blot assay. RESULTS: KGLY significantly prolonged mice survival time and ameliorated LPS-induced edema, thickening of alveolar septa and inflammatory cell infiltration in a dose-dependent manner. Additionally, KGLY markedly attenuated LPS-induced acute pulmonary inflammation via decreasing the expressions of cytokines and chemokines (IL-1beta, IL-6, TNF-alpha, and MIP-2), enhanced the activities of anti-oxidative indicators (SOD and GSH), suppressed the levels of MPO and MDA, and down-regulated the expressions of TLR4, NF-kappaB and MMP9. CONCLUSIONS: The results suggested that the relieving effect of KGLY against LPS-induced ALI might be partially due to suppression of oxidative stress and inflammatory response, inhibition of TLR4-mediated NF-kappaB activation, and down-regulation of MMP9 expression, indicating it may be a potential therapeutic agent for ALI. Twit Text FOAVip Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-kappaB signaling pathway and MMP-9 expression ????J Ethnopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27036629 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27036629 #FOAvip English Wikipedia <ref>{{Cite pmid|27036629}}</ref> Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute lung injury through inhibition of TLR4-mediated NF-kappaB signaling pathway and MMP-9 expression #MMPMID27036629 Zhang X; Sun CY; Zhang YB; Guo HZ; Feng XX; Peng SZ; Yuan J; Zheng RB; Chen WP; Su ZR; Huang XD J Ethnopharmacol 2016[Jun]; 186 (ä): 91-102 PMID27036629show ga ETHNOPHARMACOLOGICAL RELEVANCE: Kegan Liyan oral liquid (KGLY), a Chinese prescription modified from classic formulas Yin-Qiao-San (from TCM classic Wenbing Tiaobian) and Shen-Jie-San (first mentioned in Shanghan Wenyi Tiaobian), has been reported to exert heat-clearing and detoxifying effects and used extensively for the treatment of severe pulmonary diseases in clinics including influenza, cough and pneumonia. AIM OF THIS STUDY: The purpose of this study was to investigate the protective effect of KGLY on lipopolysaccharide (LPS) induced acute lung injury (ALI) in mice and to illuminate the underlying mechanisms. MATERIALS AND METHODS: Mice were orally administrated with KGLY (50, 100 and 150mg/kg) before intratracheal instillation of LPS. 24h post LPS challenge, lung tissues and the bronchoalveolar lavage fluid (BALF) were collected for lung wet/dry (W/D) weight ratio, histopathological examinations and biochemical analyses. The cell counts, protein concentration, interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein-2 (MIP-2) in BALF, superoxide dismutase (SOD), glutathione (GSH), myeloperoxidase (MPO) and malondialdehyde (MDA) levels were detected. Meanwhile, the activation of toll-like receptor 4 (TLR4), nuclear factor kappa B (NF-kappaB), as well as matrix metalloproteinases 9 (MMP-9) were determined by western blot assay. RESULTS: KGLY significantly prolonged mice survival time and ameliorated LPS-induced edema, thickening of alveolar septa and inflammatory cell infiltration in a dose-dependent manner. Additionally, KGLY markedly attenuated LPS-induced acute pulmonary inflammation via decreasing the expressions of cytokines and chemokines (IL-1beta, IL-6, TNF-alpha, and MIP-2), enhanced the activities of anti-oxidative indicators (SOD and GSH), suppressed the levels of MPO and MDA, and down-regulated the expressions of TLR4, NF-kappaB and MMP9. CONCLUSIONS: The results suggested that the relieving effect of KGLY against LPS-induced ALI might be partially due to suppression of oxidative stress and inflammatory response, inhibition of TLR4-mediated NF-kappaB activation, and down-regulation of MMP9 expression, indicating it may be a potential therapeutic agent for ALI. |Acute Lung Injury/*chemically induced/drug therapy[MESH] |Administration, Oral[MESH] |Animals[MESH] |Antioxidants/metabolism[MESH] |Bronchoalveolar Lavage Fluid/chemistry/cytology[MESH] |Cytokines/genetics/metabolism[MESH] |Drugs, Chinese Herbal/chemistry/*pharmacology[MESH] |Gene Expression Regulation/drug effects[MESH] |Lipopolysaccharides/*toxicity[MESH] |Male[MESH] |Matrix Metalloproteinase 9/genetics/*metabolism[MESH] |Mice[MESH] |Molecular Structure[MESH] |NF-kappa B/genetics/*metabolism[MESH] |Signal Transduction/drug effects[MESH] |Survival Analysis[MESH]Kegan Liyan oral liquid ameliorates lipopolysaccharide-induced acute l(epmc).pdf DeepDyve Pubget Overpricing