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10.1111/imm.12620 http://scihub22266oqcxt.onion/10.1111/imm.12620 27177697!4948035!27177697     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27177697&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27177697.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunology 2016 ; 148 (4): 420-32 Nephropedia Template TP {{tp|p=27177697|t=2016. LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages |pdf=|usr=}}{{27177697}} gab.com Text LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=27177697 #FOAvip As part of the innate host response neutrophils release neutrophil extracellular traps (NETs), protein:DNA complexes that contain a number of antimicrobial peptides (AMPs), such as cathelicidin. Human cathelicidin in its active form, LL37, has potent antimicrobial activity against bacteria. However, whether LL37 derived from NETs contributes to antimicrobial activity against intracellular pathogens remains unclear. Here, we report that NETs induced by mycobacteria contain cathelicidin. Human macrophages internalized NET-bound cathelicidin, which is transported to lysosomal compartments. Furthermore, using a model of in vitro-generated LL37:DNA complexes we found that LL37 derived from such complexes attacks mycobacteria in macrophage phagolysosomes resulting in antimicrobial activity. Taken together, our results suggest a mechanism by which LL37 in complex with DNA contributes to host defence against intracellular bacteria in human macrophages. Twit Text FOAVip LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=27177697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27177697 #FOAvip English Wikipedia <ref>{{Cite pmid|27177697}}</ref> LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages #MMPMID27177697 Stephan A; Batinica M; Steiger J; Hartmann P; Zaucke F; Bloch W; Fabri M Immunology 2016[Aug]; 148 (4): 420-32 PMID27177697show ga As part of the innate host response neutrophils release neutrophil extracellular traps (NETs), protein:DNA complexes that contain a number of antimicrobial peptides (AMPs), such as cathelicidin. Human cathelicidin in its active form, LL37, has potent antimicrobial activity against bacteria. However, whether LL37 derived from NETs contributes to antimicrobial activity against intracellular pathogens remains unclear. Here, we report that NETs induced by mycobacteria contain cathelicidin. Human macrophages internalized NET-bound cathelicidin, which is transported to lysosomal compartments. Furthermore, using a model of in vitro-generated LL37:DNA complexes we found that LL37 derived from such complexes attacks mycobacteria in macrophage phagolysosomes resulting in antimicrobial activity. Taken together, our results suggest a mechanism by which LL37 in complex with DNA contributes to host defence against intracellular bacteria in human macrophages. |Antimicrobial Cationic Peptides[MESH] |Cathelicidins/chemistry/immunology/*metabolism[MESH] |Cells, Cultured[MESH] |DNA/chemistry/immunology/*metabolism[MESH] |Endocytosis[MESH] |Extracellular Traps/metabolism[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Intracellular Space[MESH] |Macrophages/*immunology/microbiology[MESH] |Mycobacterium bovis/*immunology[MESH] |Neutrophil Activation[MESH] |Neutrophils/*immunology/microbiology[MESH] |Phagosomes/*metabolism[MESH]LL37:DNA complexes provide antimicrobial activity against intracellula(epmc).pdf DeepDyve Pubget Overpricing