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10.3109/10641968909035356

http://scihub22266oqcxt.onion/10.3109/10641968909035356
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2743585!ä!2743585

suck abstract from ncbi


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pmid2743585      Clin+Exp+Hypertens+A 1989 ; 11 (3): 487-500
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  • Decreased cytosolic free calcium concentration in lymphocytes of magnesium-supplemented DOCA-salt hypertensive rats #MMPMID2743585
  • Suzuki H; Sano H; Fukuzaki H
  • Clin Exp Hypertens A 1989[]; 11 (3): 487-500 PMID2743585show ga
  • The effect of magnesium supplementation on blood pressure and lymphocyte cytosolic free calcium concentration (L-[Ca2+]i; nM) was examined in DOCA salt hypertensive rats (DSR). Magnesium was administered for 4 weeks with a standard diet in the form of 1% MgO (850 mg magnesium/100 g). In magnesium-supplemented DSR (DS-Mg), the elevation of systolic blood pressure (SBP; mmHg) was significantly attenuated (136.7 +/- 23.0 vs 180.6 +/- 23.4, p less than 0.005) and the L-[Ca2+]i was significantly lower (70.5 +/- 7.0 vs 84.5 +/- 7.1, p less than 0.005) than in DSR which were fed the standard rat diet. Lymphocyte magnesium content (nEq/mg protein) in DSR was lower than in control rats (160.6 +/- 18.3 vs 182.3 +/- 13.9, p less than 0.05) and approximately the same as in DS-Mg (164.9 +/- 6.9, p less than 0.05 vs control). Plasma magnesium concentration was slightly higher in DS-Mg than DSR (2.53 +/- 0.35 vs 2.21 +/- 0.26). We observed a significant positive correlation between SBP and L-[Ca2+]i in DS-Mg and in DSR as a whole. These findings suggest that oral magnesium supplementation can attenuate the elevation of blood pressure and simultaneously decrease the cytosolic free calcium concentration in DOCA salt hypertensive rats.
  • |Animals[MESH]
  • |Blood Pressure/drug effects[MESH]
  • |Body Weight/drug effects[MESH]
  • |Calcium/*blood[MESH]
  • |Desoxycorticosterone[MESH]
  • |Hypertension/chemically induced/*physiopathology[MESH]
  • |Lymphocytes/*analysis/drug effects[MESH]
  • |Magnesium/*pharmacology/urine[MESH]
  • |Male[MESH]
  • |Rats[MESH]
  • |Rats, Inbred Strains[MESH]


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