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10.1016/j.yexcr.2016.09.022 http://scihub22266oqcxt.onion/10.1016/j.yexcr.2016.09.022 27693494!ä!27693494 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27693494.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Cell+Res 2016 ; 349 (1): 68-76 Nephropedia Template TP {{tp|p=27693494|t=2016. Bradykinin promotes migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2 |pdf=|usr=}}{{27693494}} gab.com Text Bradykinin promotes migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2 JO: Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=27693494 #FOAvip Tumor metastasis is the main reason of death for hepatocellular carcinoma (HCC) patients. Cell migration and invasion are two prerequisites for tumor metastasis, in which TRPM7 and MMPs play an important role. In our study, we found that bradykinin (BK) could upregulate the expression of TRPM7 and dynamically regulate the phosphorylation of non-muscle myosin IIA heavy chain (NMHC-IIA) Ser-1943 in HepG2 cells. The influx of Ca(2+) via TRPM7 was necessary for elevating the activity of m-calpain and mu-calpain. Additionally, we observed that BK stimulated HepG2 cells to secrete more MMP2 but not MMP9. Src was critical in the process of MMP2 secretion and invadopodia formation. The heat map showed that BDKRB2, TRPM7 and MMP2 had higher overexpression proportions in 25 HCC cell lines. Some clinical specimens of HCC also indicated that BDKRB2 and MMP2 were overexpressed. In conclusion, BK promoted migration and invasion of HCC cells through TRPM7 and MMP2. Twit Text FOAVip Bradykinin promotes migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2 ????Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=27693494 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27693494 #FOAvip English Wikipedia <ref>{{Cite pmid|27693494}}</ref> Bradykinin promotes migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2 #MMPMID27693494 Chen Y; Yu Y; Sun S; Wang Z; Liu P; Liu S; Jiang J Exp Cell Res 2016[Nov]; 349 (1): 68-76 PMID27693494show ga Tumor metastasis is the main reason of death for hepatocellular carcinoma (HCC) patients. Cell migration and invasion are two prerequisites for tumor metastasis, in which TRPM7 and MMPs play an important role. In our study, we found that bradykinin (BK) could upregulate the expression of TRPM7 and dynamically regulate the phosphorylation of non-muscle myosin IIA heavy chain (NMHC-IIA) Ser-1943 in HepG2 cells. The influx of Ca(2+) via TRPM7 was necessary for elevating the activity of m-calpain and mu-calpain. Additionally, we observed that BK stimulated HepG2 cells to secrete more MMP2 but not MMP9. Src was critical in the process of MMP2 secretion and invadopodia formation. The heat map showed that BDKRB2, TRPM7 and MMP2 had higher overexpression proportions in 25 HCC cell lines. Some clinical specimens of HCC also indicated that BDKRB2 and MMP2 were overexpressed. In conclusion, BK promoted migration and invasion of HCC cells through TRPM7 and MMP2. |Bradykinin/*pharmacology[MESH] |Calcium/metabolism[MESH] |Calpain/metabolism[MESH] |Carcinoma, Hepatocellular/enzymology/*metabolism/*pathology[MESH] |Cell Movement/*drug effects[MESH] |Exocytosis/drug effects[MESH] |Gene Expression Regulation, Neoplastic/drug effects[MESH] |Hep G2 Cells[MESH] |Humans[MESH] |Liver Neoplasms/enzymology/*metabolism/*pathology[MESH] |Matrix Metalloproteinase 2/*metabolism[MESH] |Molecular Motor Proteins/metabolism[MESH] |Myosin Heavy Chains/metabolism[MESH] |Neoplasm Invasiveness[MESH] |Phosphorylation/drug effects[MESH] |Phosphoserine/metabolism[MESH] |Podosomes/drug effects/metabolism[MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism[MESH] |RNA Interference[MESH] |RNA, Messenger/genetics/metabolism[MESH] |Receptor, Bradykinin B2/metabolism[MESH] |Signal Transduction/drug effects[MESH] |TRPM Cation Channels/genetics/*metabolism[MESH] |Up-Regulation/drug effects[MESH]Bradykinin promotes migration and invasion of hepatocellular carcinoma(epmc).pdf DeepDyve Pubget Overpricing