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10.1038/srep34592 http://scihub22266oqcxt.onion/10.1038/srep34592 27698370!5048179!27698370     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27698370.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 34592 Nephropedia Template TP {{tp|p=27698370|t=2016. Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy |pdf=|usr=}}{{27698370}} gab.com Text Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27698370 #FOAvip We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac morphological and biochemical changes consistent with human uremic cardiomyopathy. Both inhibition of Na/K-ATPase oxidant amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy. In a reversal study, administration of pNaKtide after the induction of uremic cardiomyopathy reversed many of the phenotypical features. Attenuation of Na/K-ATPase oxidant amplification may be a potential strategy for clinical therapy of this disorder. Twit Text FOAVip Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27698370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27698370 #FOAvip English Wikipedia <ref>{{Cite pmid|27698370}}</ref> Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy #MMPMID27698370 Liu J; Tian J; Chaudhry M; Maxwell K; Yan Y; Wang X; Shah PT; Khawaja AA; Martin R; Robinette TJ; El-Hamdani A; Dodrill MW; Sodhi K; Drummond CA; Haller ST; Kennedy DJ; Abraham NG; Xie Z; Shapiro JI Sci Rep 2016[Oct]; 6 (ä): 34592 PMID27698370show ga We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac morphological and biochemical changes consistent with human uremic cardiomyopathy. Both inhibition of Na/K-ATPase oxidant amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy. In a reversal study, administration of pNaKtide after the induction of uremic cardiomyopathy reversed many of the phenotypical features. Attenuation of Na/K-ATPase oxidant amplification may be a potential strategy for clinical therapy of this disorder. |Animals[MESH] |Cardiomyopathies/*therapy[MESH] |Disease Models, Animal[MESH] |Enzyme Activators/administration & dosage[MESH] |Enzyme Inhibitors/*administration & dosage[MESH] |Heme Oxygenase-1/metabolism[MESH] |Male[MESH] |Mice, Inbred C57BL[MESH] |Oxidants/*metabolism[MESH] |Protoporphyrins/administration & dosage[MESH] |Reactive Oxygen Species/metabolism[MESH] |Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors/*metabolism[MESH] |Treatment Outcome[MESH]Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtid(epmc).pdf DeepDyve Pubget Overpricing