Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/srep35759 http://scihub22266oqcxt.onion/10.1038/srep35759 27775080!5075947!27775080     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27775080&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27775080.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (�): 35759 Nephropedia Template TP {{tp|p=27775080|t=2016. Substitution rate and natural selection in parvovirus B19 |pdf=|usr=}}{{27775080}} gab.com Text Substitution rate and natural selection in parvovirus B19 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27775080 #FOAvip The aim of this study was to estimate substitution rate and imprints of natural selection on parvovirus B19 genotype 1. Studied datasets included 137 near complete coding B19 genomes (positions 665 to 4851) for phylogenetic and substitution rate analysis and 146 and 214 partial genomes for selection analyses in open reading frames ORF1 and ORF2, respectively, collected 1973-2012 and including 9 newly sequenced isolates from Serbia. Phylogenetic clustering assigned majority of studied isolates to G1A. Nucleotide substitution rate for total coding DNA was 1.03 (0.6-1.27) x 10(-4) substitutions/site/year, with higher values for analyzed genome partitions. In spite of the highest evolutionary rate, VP2 codons were found to be under purifying selection with rare episodic positive selection, whereas codons under diversifying selection were found in the unique part of VP1, known to contain B19 immune epitopes important in persistent infection. Analyses of overlapping gene regions identified nucleotide positions under opposite selective pressure in different ORFs, suggesting complex evolutionary mechanisms of nucleotide changes in B19 viral genomes. Twit Text FOAVip Substitution rate and natural selection in parvovirus B19 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27775080 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27775080 #FOAvip English Wikipedia <ref>{{Cite pmid|27775080}}</ref> Substitution rate and natural selection in parvovirus B19 #MMPMID27775080 Stamenkovic GG; Cirkovic VS; Siljic MM; Blagojevic JV; Knezevic AM; Joksic ID; Stanojevic MP Sci Rep 2016[Oct]; 6 (�): 35759 PMID27775080show ga The aim of this study was to estimate substitution rate and imprints of natural selection on parvovirus B19 genotype 1. Studied datasets included 137 near complete coding B19 genomes (positions 665 to 4851) for phylogenetic and substitution rate analysis and 146 and 214 partial genomes for selection analyses in open reading frames ORF1 and ORF2, respectively, collected 1973-2012 and including 9 newly sequenced isolates from Serbia. Phylogenetic clustering assigned majority of studied isolates to G1A. Nucleotide substitution rate for total coding DNA was 1.03 (0.6-1.27) x 10(-4) substitutions/site/year, with higher values for analyzed genome partitions. In spite of the highest evolutionary rate, VP2 codons were found to be under purifying selection with rare episodic positive selection, whereas codons under diversifying selection were found in the unique part of VP1, known to contain B19 immune epitopes important in persistent infection. Analyses of overlapping gene regions identified nucleotide positions under opposite selective pressure in different ORFs, suggesting complex evolutionary mechanisms of nucleotide changes in B19 viral genomes. |Capsid Proteins/genetics[MESH] |Capsid/metabolism[MESH] |Codon/genetics[MESH] |DNA, Viral/genetics[MESH] |Epitopes/genetics[MESH] |Genetic Variation/*genetics[MESH] |Genome, Viral/genetics[MESH] |Genotype[MESH] |Humans[MESH] |Immunoglobulin G/genetics[MESH] |Immunoglobulin M/genetics[MESH] |Nucleotides/genetics[MESH] |Open Reading Frames/genetics[MESH] |Parvoviridae Infections/virology[MESH] |Parvovirus B19, Human/*genetics[MESH] |Phylogeny[MESH] |Selection, Genetic/*genetics[MESH]Substitution rate and natural selection in parvovirus B19 (epmc).pdf DeepDyve Pubget Overpricing