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10.3390/molecules22010030

http://scihub22266oqcxt.onion/10.3390/molecules22010030
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28035990!6155917!28035990
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suck abstract from ncbi


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pmid28035990      Molecules 2016 ; 22 (1): ä
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  • Dysregulation of Cell Death and Its Epigenetic Mechanisms in Systemic Lupus Erythematosus #MMPMID28035990
  • Wu H; Fu S; Zhao M; Lu L; Lu Q
  • Molecules 2016[Dec]; 22 (1): ä PMID28035990show ga
  • Systemic lupus erythematosus (SLE) is a systemic autoimmune disease involving multiple organs and tissues, which is characterized by the presence of excessive anti-nuclear autoantibodies. The pathogenesis of SLE has been intensively studied but remains far from clear. Increasing evidence has shown that the genetic susceptibilities and environmental factors-induced abnormalities in immune cells, dysregulation of apoptosis, and defects in the clearance of apoptotic materials contribute to the development of SLE. As the main source of auto-antigens, aberrant cell death may play a critical role in the pathogenesis of SLE. In this review, we summarize up-to-date research progress on different levels of cell death-including increasing rate of apoptosis, necrosis, autophagy and defects in clearance of dying cells-and discuss the possible underlying mechanisms, especially epigenetic modifications, which may provide new insight in the potential development of therapeutic strategies for SLE.
  • |Apoptosis/genetics/*immunology[MESH]
  • |Autoantibodies/immunology[MESH]
  • |Autoantigens/immunology[MESH]
  • |Autophagy/genetics/*immunology[MESH]
  • |DNA Methylation/genetics[MESH]
  • |Dendritic Cells/immunology[MESH]
  • |Epigenesis, Genetic/*genetics[MESH]
  • |Humans[MESH]
  • |Lupus Erythematosus, Systemic/genetics/*immunology/*pathology[MESH]
  • |Macrophages/immunology[MESH]


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