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10.1089/jmf.2016.3817 http://scihub22266oqcxt.onion/10.1089/jmf.2016.3817 28060552!ä!28060552 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28060552.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Med+Food 2017 ; 20 (1): 56-64 Nephropedia Template TP {{tp|p=28060552|t=2017. The Root Extract of Gentiana macrophylla Pall Alleviates B19-NS1-Exacerbated Liver Injuries in NZB/W F1 Mice |pdf=|usr=}}{{28060552}} gab.com Text The Root Extract of Gentiana macrophylla Pall Alleviates B19-NS1-Exacerbated Liver Injuries in NZB/W F1 Mice JO: J Med Food http://www.kidney.de/pget.php?&tw=1&pmid=28060552 #FOAvip The nonstructural protein NS1 of human parvovirus B19 (B19) is known to exacerbate disease activity in systemic lupus erythematosus (SLE). However, no specific medicine for B19 infection is available. The roots of Gentiana macrophylla Pall. (GM), the traditional Chinese medicine "Qinjiao," have been used for centuries to treat rheumatic disease, including SLE. Herein, we aimed to investigate the effects of GM root extract (100 and 300 mg/kg body weight) on B19-NS1-exacerbated liver injury in NZB/W F1 mice; liver tissues were assessed by hematoxylin-eosin staining and immunoblotting. The GM root extract significantly decreased B19-NS1-exacerbated liver inflammation by suppressing the expressions of hepatic inducible nitric oxide synthase, cyclooxygenase type 2 (COX-2), interleukin (IL)-1beta proteins, values of serum asparate transaminase (AST) and alanine transaminase (ALT), and lymphocyte infiltration (P < .05). It also significantly reduced the B19-NS1-exacerbated hepatic matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA) expressions by downregulating tumor necrosis factor (TNF)-alpha/NF-kappaB (p65) signaling. These findings suggest a therapeutic potential of GM root extract against B19-NS1-exacerbated liver inflammation in SLE. Twit Text FOAVip The Root Extract of Gentiana macrophylla Pall Alleviates B19-NS1-Exacerbated Liver Injuries in NZB/W F1 Mice ????J Med Food http://www.kidney.de/pget.php?&tw=1&pmid=28060552 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28060552 #FOAvip English Wikipedia <ref>{{Cite pmid|28060552}}</ref> The Root Extract of Gentiana macrophylla Pall Alleviates B19-NS1-Exacerbated Liver Injuries in NZB/W F1 Mice #MMPMID28060552 Sheu MJ; Chiu CC; Yang DJ; Hsu TC; Tzang BS J Med Food 2017[Jan]; 20 (1): 56-64 PMID28060552show ga The nonstructural protein NS1 of human parvovirus B19 (B19) is known to exacerbate disease activity in systemic lupus erythematosus (SLE). However, no specific medicine for B19 infection is available. The roots of Gentiana macrophylla Pall. (GM), the traditional Chinese medicine "Qinjiao," have been used for centuries to treat rheumatic disease, including SLE. Herein, we aimed to investigate the effects of GM root extract (100 and 300 mg/kg body weight) on B19-NS1-exacerbated liver injury in NZB/W F1 mice; liver tissues were assessed by hematoxylin-eosin staining and immunoblotting. The GM root extract significantly decreased B19-NS1-exacerbated liver inflammation by suppressing the expressions of hepatic inducible nitric oxide synthase, cyclooxygenase type 2 (COX-2), interleukin (IL)-1beta proteins, values of serum asparate transaminase (AST) and alanine transaminase (ALT), and lymphocyte infiltration (P < .05). It also significantly reduced the B19-NS1-exacerbated hepatic matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA) expressions by downregulating tumor necrosis factor (TNF)-alpha/NF-kappaB (p65) signaling. These findings suggest a therapeutic potential of GM root extract against B19-NS1-exacerbated liver inflammation in SLE. |Animals[MESH] |Cyclooxygenase 2/genetics/immunology[MESH] |Female[MESH] |Gentiana/*chemistry[MESH] |Humans[MESH] |Interleukin-1beta/genetics/immunology[MESH] |Liver Diseases/*drug therapy/genetics/immunology/*virology[MESH] |Liver/drug effects/immunology[MESH] |Matrix Metalloproteinase 9/genetics/immunology[MESH] |Mice[MESH] |Mice, Inbred NZB[MESH] |Nitric Oxide Synthase Type II/genetics/immunology[MESH] |Parvoviridae Infections/drug therapy/genetics/immunology/virology[MESH] |Parvovirus B19, Human/*drug effects/physiology[MESH]The Root Extract of Gentiana macrophylla Pall Alleviates B19-NS1-Exac(epmc).pdf DeepDyve Pubget Overpricing