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10.1186/s12865-016-0187-3 http://scihub22266oqcxt.onion/10.1186/s12865-016-0187-3 28061847!5219689!28061847     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28061847&cmd=llinks): Failed to open stream: HTTP request failed! 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Role of intestinal microbiota and metabolites on gut homeostasis and human diseases |pdf=|usr=}}{{28061847}} gab.com Text Role of intestinal microbiota and metabolites on gut homeostasis and human diseases JO: BMC Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28061847 #FOAvip BACKGROUND: A vast diversity of microbes colonizes in the human gastrointestinal tract, referred to intestinal microbiota. Microbiota and products thereof are indispensable for shaping the development and function of host innate immune system, thereby exerting multifaceted impacts in gut health. METHODS: This paper reviews the effects on immunity of gut microbe-derived nucleic acids, and gut microbial metabolites, as well as the involvement of commensals in the gut homeostasis. We focus on the recent findings with an intention to illuminate the mechanisms by which the microbiota and products thereof are interacting with host immunity, as well as to scrutinize imbalanced gut microbiota (dysbiosis) which lead to autoimmune disorders including inflammatory bowel disease (IBD), Type 1 diabetes (T1D) and systemic immune syndromes such as rheumatoid arthritis (RA). RESULTS: In addition to their well-recognized benefits in the gut such as occupation of ecological niches and competition with pathogens, commensal bacteria have been shown to strengthen the gut barrier and to exert immunomodulatory actions within the gut and beyond. It has been realized that impaired intestinal microbiota not only contribute to gut diseases but also are inextricably linked to metabolic disorders and even brain dysfunction. CONCLUSIONS: A better understanding of the mutual interactions of the microbiota and host immune system, would shed light on our endeavors of disease prevention and broaden the path to our discovery of immune intervention targets for disease treatment. Twit Text FOAVip Role of intestinal microbiota and metabolites on gut homeostasis and human diseases ????BMC Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28061847 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28061847 #FOAvip English Wikipedia <ref>{{Cite pmid|28061847}}</ref> Role of intestinal microbiota and metabolites on gut homeostasis and human diseases #MMPMID28061847 Lin L; Zhang J BMC Immunol 2017[Jan]; 18 (1): 2 PMID28061847show ga BACKGROUND: A vast diversity of microbes colonizes in the human gastrointestinal tract, referred to intestinal microbiota. Microbiota and products thereof are indispensable for shaping the development and function of host innate immune system, thereby exerting multifaceted impacts in gut health. METHODS: This paper reviews the effects on immunity of gut microbe-derived nucleic acids, and gut microbial metabolites, as well as the involvement of commensals in the gut homeostasis. We focus on the recent findings with an intention to illuminate the mechanisms by which the microbiota and products thereof are interacting with host immunity, as well as to scrutinize imbalanced gut microbiota (dysbiosis) which lead to autoimmune disorders including inflammatory bowel disease (IBD), Type 1 diabetes (T1D) and systemic immune syndromes such as rheumatoid arthritis (RA). RESULTS: In addition to their well-recognized benefits in the gut such as occupation of ecological niches and competition with pathogens, commensal bacteria have been shown to strengthen the gut barrier and to exert immunomodulatory actions within the gut and beyond. It has been realized that impaired intestinal microbiota not only contribute to gut diseases but also are inextricably linked to metabolic disorders and even brain dysfunction. CONCLUSIONS: A better understanding of the mutual interactions of the microbiota and host immune system, would shed light on our endeavors of disease prevention and broaden the path to our discovery of immune intervention targets for disease treatment. |*Homeostasis[MESH] |Animals[MESH] |Arthritis, Rheumatoid/*immunology/microbiology[MESH] |DNA, Bacterial/*immunology[MESH] |Diabetes Mellitus, Type 1/*immunology/microbiology[MESH] |Dysbiosis/*immunology/microbiology[MESH] |Gastrointestinal Microbiome/*physiology[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inflammatory Bowel Diseases/*immunology/microbiology[MESH] |Receptors, Pattern Recognition/metabolism[MESH]Role of intestinal microbiota and metabolites on gut homeostasis and h(epmc).pdf DeepDyve Pubget Overpricing