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10.1053/j.ackd.2016.11.011 http://scihub22266oqcxt.onion/10.1053/j.ackd.2016.11.011 28284376!5351778!28284376     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28284376&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28284376.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Chronic+Kidney+Dis 2017 ; 24 (2): 107-116 Nephropedia Template TP {{tp|p=28284376|t=2017. The Tubulointerstitial Pathophysiology of Progressive Kidney Disease |pdf=|usr=}}{{28284376}} gab.com Text The Tubulointerstitial Pathophysiology of Progressive Kidney Disease JO: Adv Chronic Kidney Dis http://www.kidney.de/pget.php?&tw=1&pmid=28284376 #FOAvip Accumulating evidence suggests that the central locus for the progression of CKD is the renal proximal tubule. As injured tubular epithelial cells dedifferentiate in attempted repair, they stimulate inflammation and recruit myofibroblasts. At the same time, tissue loss stimulates remnant nephron hypertrophy. Increased tubular transport workload eventually exceeds the energy-generating capacity of the hypertrophied nephrons, leading to anerobic metabolism, acidosis, hypoxia, endoplasmic reticulum stress, and the induction of additional inflammatory and fibrogenic responses. The result is a vicious cycle of injury, misdirected repair, maladaptive responses, and more nephron loss. Therapy that might be advantageous at one phase of this progression pathway could be deleterious during other phases. Thus, interrupting this downward spiral requires narrowly targeted approaches that promote healing and adequate function without generating further entry into the progression cycle. Twit Text FOAVip The Tubulointerstitial Pathophysiology of Progressive Kidney Disease ????Adv Chronic Kidney Dis http://www.kidney.de/pget.php?&tw=1&pmid=28284376 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28284376 #FOAvip English Wikipedia <ref>{{Cite pmid|28284376}}</ref> The Tubulointerstitial Pathophysiology of Progressive Kidney Disease #MMPMID28284376 Schnaper HW Adv Chronic Kidney Dis 2017[Mar]; 24 (2): 107-116 PMID28284376show ga Accumulating evidence suggests that the central locus for the progression of CKD is the renal proximal tubule. As injured tubular epithelial cells dedifferentiate in attempted repair, they stimulate inflammation and recruit myofibroblasts. At the same time, tissue loss stimulates remnant nephron hypertrophy. Increased tubular transport workload eventually exceeds the energy-generating capacity of the hypertrophied nephrons, leading to anerobic metabolism, acidosis, hypoxia, endoplasmic reticulum stress, and the induction of additional inflammatory and fibrogenic responses. The result is a vicious cycle of injury, misdirected repair, maladaptive responses, and more nephron loss. Therapy that might be advantageous at one phase of this progression pathway could be deleterious during other phases. Thus, interrupting this downward spiral requires narrowly targeted approaches that promote healing and adequate function without generating further entry into the progression cycle. |Acute Kidney Injury/complications/metabolism/pathology[MESH] |Animals[MESH] |Cell Dedifferentiation[MESH] |Disease Progression[MESH] |Extracellular Matrix/metabolism[MESH] |Fibrosis[MESH] |Homeostasis[MESH] |Humans[MESH] |Hyperplasia/pathology[MESH] |Kidney Tubules, Proximal/*metabolism/*pathology[MESH] |Nephritis, Interstitial/*complications/*physiopathology[MESH]The Tubulointerstitial Pathophysiology of Progressive Kidney Disease (epmc).pdf DeepDyve Pubget Overpricing