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10.1152/ajprenal.00680.2016 http://scihub22266oqcxt.onion/10.1152/ajprenal.00680.2016 28539338!ä!28539338 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28539338.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Renal+Physiol 2017 ; 313 (3): F629-F640 Nephropedia Template TP {{tp|p=28539338|t=2017. Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation |pdf=|usr=}}{{28539338}} gab.com Text Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28539338 #FOAvip Significant alterations in maternal calcium (Ca(2+)) and magnesium (Mg(2+)) balance occur during lactation. Ca(2+) is the primary divalent cation mobilized into breast milk by demineralization of the skeleton and alterations in intestinal and renal Ca(2+) transport. Mg(2+) is also concentrated in breast milk, but the underlying mechanisms are not well understood. To determine the molecular alterations in Ca(2+) and Mg(2+) transport in the intestine and kidney during lactation, three groups of female mice consisting of either nonpregnant controls, lactating mice, or mice undergoing involution were examined. The fractional excretion of Ca(2+), but not Mg(2+), rose significantly during lactation. Renal 1-alpha hydroxylase and 24-OHase mRNA levels increased markedly, as did plasma 1,25 dihydroxyvitamin D levels. This was accompanied by significant increases in intestinal expression of Trpv6 and S100g in lactating mice. However, no alterations in the expression of cation-permeable claudin-2, claudin-12, or claudins-15 were found in the intestine. In the kidney, increased expression of Trpv5 and Calb1 was observed during lactation, while no changes in claudins involved in Ca(2+) and Mg(2+) transport (claudin-2, claudin-14, claudin-16, or claudin-19) were found. Consistent with the mRNA expression, expression of both calbindin-D(28K) and transient receptor potential vanilloid 5 (TRPV5) proteins increased. Colonic Trpm6 expression increased during lactation, while renal Trpm6 remained unaltered. In conclusion, proteins involved in transcellular Ca(2+) and Mg(2+) transport pathways increase during lactation, while expression of paracellular transport proteins remained unchanged. Increased fractional Ca(2+) excretion can be explained by vitamin D-dependent intestinal hyperabsorption and bone demineralization, despite enhanced transcellular Ca(2+) uptake by the kidney. Twit Text FOAVip Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28539338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28539338 #FOAvip English Wikipedia <ref>{{Cite pmid|28539338}}</ref> Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation #MMPMID28539338 Beggs MR; Appel I; Svenningsen P; Skjodt K; Alexander RT; Dimke H Am J Physiol Renal Physiol 2017[Sep]; 313 (3): F629-F640 PMID28539338show ga Significant alterations in maternal calcium (Ca(2+)) and magnesium (Mg(2+)) balance occur during lactation. Ca(2+) is the primary divalent cation mobilized into breast milk by demineralization of the skeleton and alterations in intestinal and renal Ca(2+) transport. Mg(2+) is also concentrated in breast milk, but the underlying mechanisms are not well understood. To determine the molecular alterations in Ca(2+) and Mg(2+) transport in the intestine and kidney during lactation, three groups of female mice consisting of either nonpregnant controls, lactating mice, or mice undergoing involution were examined. The fractional excretion of Ca(2+), but not Mg(2+), rose significantly during lactation. Renal 1-alpha hydroxylase and 24-OHase mRNA levels increased markedly, as did plasma 1,25 dihydroxyvitamin D levels. This was accompanied by significant increases in intestinal expression of Trpv6 and S100g in lactating mice. However, no alterations in the expression of cation-permeable claudin-2, claudin-12, or claudins-15 were found in the intestine. In the kidney, increased expression of Trpv5 and Calb1 was observed during lactation, while no changes in claudins involved in Ca(2+) and Mg(2+) transport (claudin-2, claudin-14, claudin-16, or claudin-19) were found. Consistent with the mRNA expression, expression of both calbindin-D(28K) and transient receptor potential vanilloid 5 (TRPV5) proteins increased. Colonic Trpm6 expression increased during lactation, while renal Trpm6 remained unaltered. In conclusion, proteins involved in transcellular Ca(2+) and Mg(2+) transport pathways increase during lactation, while expression of paracellular transport proteins remained unchanged. Increased fractional Ca(2+) excretion can be explained by vitamin D-dependent intestinal hyperabsorption and bone demineralization, despite enhanced transcellular Ca(2+) uptake by the kidney. |25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics/metabolism[MESH] |Adaptation, Physiological[MESH] |Animals[MESH] |Biological Transport[MESH] |Calbindin 1/genetics/metabolism[MESH] |Calcium Channels/genetics/metabolism[MESH] |Calcium/*metabolism/urine[MESH] |Claudins/genetics/metabolism[MESH] |Epithelial Cells/*metabolism[MESH] |Female[MESH] |Intestinal Absorption[MESH] |Intestinal Mucosa/cytology/*metabolism[MESH] |Kidney/cytology/*metabolism[MESH] |Lactation/*metabolism[MESH] |Magnesium/*metabolism[MESH] |Mammary Glands, Animal/*metabolism[MESH] |Membrane Transport Proteins/genetics/*metabolism[MESH] |Mice[MESH] |Renal Reabsorption[MESH] |S100 Calcium Binding Protein G/genetics/metabolism[MESH] |TRPM Cation Channels/genetics/metabolism[MESH] |TRPV Cation Channels/genetics/metabolism[MESH] |Time Factors[MESH] |Vitamin D/analogs & derivatives/blood[MESH]Expression of transcellular and paracellular calcium and magnesium tra(epmc).pdf DeepDyve Pubget Overpricing