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10.1016/s0140-6736(85)91207-3

http://scihub22266oqcxt.onion/10.1016/s0140-6736(85)91207-3
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2857901!ä!2857901

suck abstract from ncbi


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pmid2857901      Lancet 1985 ; 1 (8428): 545-9
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  • Renal, haemodynamic, and hormonal effects of human alpha atrial natriuretic peptide in healthy volunteers #MMPMID2857901
  • Richards AM; Nicholls MG; Ikram H; Webster MW; Yandle TG; Espiner EA
  • Lancet 1985[Mar]; 1 (8428): 545-9 PMID2857901show ga
  • The effects of atrial natriuretic peptide (ANP) were investigated in six healthy male volunteers taking a constant diet (120 mmol sodium and 60 mmol potassium daily). They were given an intravenous bolus of 100 micrograms human alpha-ANP on one day or placebo on another day 1-3 weeks apart in a double-blind randomised study. After ANP, urinary sodium excretion increased four-fold, and urine volume, calcium, magnesium, and phosphorus excretion doubled within 30 min of the injection. ANP induced an immediate fall in arterial pressure, followed by a longer vasodepressor phase which exceeded the duration of the effect on electrolyte excretion. There were no significant changes in plasma renin activity, aldosterone, antidiuretic hormone, or noradrenaline when compared with placebo.
  • |Atrial Natriuretic Factor[MESH]
  • |Blood Pressure/drug effects[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Double-Blind Method[MESH]
  • |Electrolytes/urine[MESH]
  • |Heart Rate/drug effects[MESH]
  • |Hemodynamics/*drug effects[MESH]
  • |Hormones/*blood[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Muscle Proteins/*pharmacology[MESH]
  • |Natriuresis/*drug effects[MESH]


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