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10.1016/j.diff.2017.06.001 http://scihub22266oqcxt.onion/10.1016/j.diff.2017.06.001 28609676!ä!28609676 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28609676.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Differentiation 2017 ; 96 (ä): 15-25 Nephropedia Template TP {{tp|p=28609676|t=2017. Hepatocellular differentiation status is characterized by distinct subnuclear localization and form of the chanzyme TRPM7 |pdf=|usr=}}{{28609676}} gab.com Text Hepatocellular differentiation status is characterized by distinct subnuclear localization and form of the chanzyme TRPM7 JO: Differentiation http://www.kidney.de/pget.php?&tw=1&pmid=28609676 #FOAvip The channel-kinase TRPM7 is important for the survival, proliferation, and differentiation, of many cell types. Both plasma membrane channel activity and kinase function are implicated in these roles. Channel activity is greater in less differentiated hepatoma cells compared with non-dividing, terminally differentiated adult hepatocytes, suggesting differences in protein expression and/or localization. We used electrophysiological and immunofluorescence approaches to establish whether hepatocellular differentiation is associated with altered TRPM7 expression. Mean outward current decreased by 44% in WIF-B hepatoma cells incubated with the established hepatic differentiating factors oncostatin M/dexamethasone for 1-8 days. Pre-incubation with pyridone 6, a pan-JAK inhibitor, blocked the current reduction. An antibody targeted to the C-terminus of TRPM7 labelled the cytoplasm in WIF-B cells and intact rat liver. Significant label also localized to the nuclear envelope (NE), with relatively more detected in adult hepatocytes compared with WIF-B cells. Hepatoma cells also exhibited nucleoplasmic labelling with intense signal in the nucleolus. The endogenous labelling pattern closely resembles that of HEK293T cells heterologously expressing a TRPM7 kinase construct containing a putative nucleolar localization sequence. These results suggest that TRPM7 form and distribution between the plasma membrane and nucleus, rather than expression, is altered in parallel with differentiation status in rat hepatic cells. Twit Text FOAVip Hepatocellular differentiation status is characterized by distinct subnuclear localization and form of the chanzyme TRPM7 ????Differentiation http://www.kidney.de/pget.php?&tw=1&pmid=28609676 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28609676 #FOAvip English Wikipedia <ref>{{Cite pmid|28609676}}</ref> Hepatocellular differentiation status is characterized by distinct subnuclear localization and form of the chanzyme TRPM7 #MMPMID28609676 Ogunrinde A; Pereira RD; Beaton N; Lam DH; Whetstone C; Hill CE Differentiation 2017[Jul]; 96 (ä): 15-25 PMID28609676show ga The channel-kinase TRPM7 is important for the survival, proliferation, and differentiation, of many cell types. Both plasma membrane channel activity and kinase function are implicated in these roles. Channel activity is greater in less differentiated hepatoma cells compared with non-dividing, terminally differentiated adult hepatocytes, suggesting differences in protein expression and/or localization. We used electrophysiological and immunofluorescence approaches to establish whether hepatocellular differentiation is associated with altered TRPM7 expression. Mean outward current decreased by 44% in WIF-B hepatoma cells incubated with the established hepatic differentiating factors oncostatin M/dexamethasone for 1-8 days. Pre-incubation with pyridone 6, a pan-JAK inhibitor, blocked the current reduction. An antibody targeted to the C-terminus of TRPM7 labelled the cytoplasm in WIF-B cells and intact rat liver. Significant label also localized to the nuclear envelope (NE), with relatively more detected in adult hepatocytes compared with WIF-B cells. Hepatoma cells also exhibited nucleoplasmic labelling with intense signal in the nucleolus. The endogenous labelling pattern closely resembles that of HEK293T cells heterologously expressing a TRPM7 kinase construct containing a putative nucleolar localization sequence. These results suggest that TRPM7 form and distribution between the plasma membrane and nucleus, rather than expression, is altered in parallel with differentiation status in rat hepatic cells. |*Cell Differentiation[MESH] |Active Transport, Cell Nucleus[MESH] |Animals[MESH] |Benzimidazoles/pharmacology[MESH] |Cell Nucleolus/*metabolism[MESH] |HEK293 Cells[MESH] |Hepatocytes/*cytology/drug effects/metabolism[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Nuclear Envelope/*metabolism[MESH] |Protein Kinase Inhibitors/pharmacology[MESH] |Pyridones/pharmacology[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH]Hepatocellular differentiation status is characterized by distinct sub(epmc).pdf DeepDyve Pubget Overpricing